EC 7.6.2.3 - ABC-type glutathione-S-conjugate transporter

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IntEnz Enzyme Nomenclature
EC 7.6.2.3

Names

Accepted name:
ABC-type glutathione-S-conjugate transporter
Other names:
multidrug resistance-associated protein 1
glutathione-S-conjugate-translocating ATPase
MRP
MRP1
ABCC1 (gene name)
YBT1 (gene name)
YCF1 (gene name)
Systematic name:
ATP phosphohydrolase (ABC-type, glutathione-S-conjugate-exporting)

Reaction

Comments:

A eukaryotic ATP-binding cassette (ABC) type transporter that mediates the transport of glutathione-S-conjugates. The mammalian enzyme, which also transports some glucuronides, exports the substrates out of the cell, while plant and fungal transporters export them into the vacuole. Over-expression confers resistance to anticancer drugs by their efficient exportation in glutathione-S-conjugate form.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0015431
UniProtKB/Swiss-Prot:

References

  1. Zaman, G. J., Flens, M. J., van Leusden, M. R., de Haas, M., Mulder, H. S., Lankelma, J., Pinedo, H. M., Scheper, R. J., Baas, F., Broxterman, H. J.
    The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.
    Proc. Natl. Acad. Sci. U.S.A. 91: 8822-8826 (1994). [PMID: 7916458]
  2. Lautier, D., Canitrot, Y., Deeley, R. G., Cole, S. P.
    Multidrug resistance mediated by the multidrug resistance protein (MRP) gene.
    Biochem. Pharmacol. 52: 967-977 (1996). [PMID: 8831715]
  3. Li, Z. S., Szczypka, M., Lu, Y. P., Thiele, D. J., Rea, P. A.
    The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pump.
    J. Biol. Chem. 271: 6509-6517 (1996). [PMID: 8626454]
  4. Lu, Y. P., Li, Z. S., Rea, P. A.
    AtMRP1 gene of Arabidopsis encodes a glutathione S-conjugate pump: isolation and functional definition of a plant ATP-binding cassette transporter gene.
    Proc. Natl. Acad. Sci. U.S.A. 94: 8243-8248 (1997). [PMID: 9223346]
  5. Cole, S. P.
    Multidrug resistance protein 1 (MRP1, ABCC1), a "multitasking" ATP-binding cassette (ABC) transporter.
    J. Biol. Chem. 289: 30880-30888 (2014). [PMID: 25281745]
  6. Cordente, A. G., Capone, D. L., Curtin, C. D.
    Unravelling glutathione conjugate catabolism in Saccharomyces cerevisiae: the role of glutathione/dipeptide transporters and vacuolar function in the release of volatile sulfur compounds 3-mercaptohexan-1-ol and 4-mercapto-4-methylpentan-2-one.
    Appl. Microbiol. Biotechnol. 99: 9709-9722 (2015). [PMID: 26227410]

[EC 7.6.2.3 created 2018]