EC 7.4.2.9 - ABC-type dipeptide transporter

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IntEnz Enzyme Nomenclature
EC 7.4.2.9

Names

Accepted name:
ABC-type dipeptide transporter
Other names:
dipeptide transporting ATPase
dipeptide ABC transporter
dppBCDF (gene names)
Systematic name:
ATP phosphohydrolase (ABC-type, dipeptide-transporting)

Reaction

Comments:

ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the uptake of di- and tripeptides. The enzyme from Pseudomonas aeruginosa can interact with five different substrate binding proteins.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Abouhamad, W. N., Manson, M., Gibson, M. M., Higgins, C. F.
    Peptide transport and chemotaxis in Escherichia coli and Salmonella typhimurium: characterization of the dipeptide permease (Dpp) and the dipeptide-binding protein.
    Mol. Microbiol. 5 : 1035-1047 (1991). [PMID: 1956284]
  2. Sanz, Y., Lanfermeijer, F. C., Renault, P., Bolotin, A., Konings, W. N., Poolman, B.
    Genetic and functional characterization of dpp genes encoding a dipeptide transport system in Lactococcus lactis.
    Arch. Microbiol. 175 : 334-343 (2001). [PMID: 11409543]
  3. Li, X., Zhuo, W., Yu, J., Ge, J., Gu, J., Feng, Y., Yang, M., Wang, L., Wang, N.
    Structure of the nucleotide-binding domain of a dipeptide ABC transporter reveals a novel iron-sulfur cluster-binding domain.
    Acta Crystallogr. D Biol. Crystallogr. 69 : 256-265 (2013). [PMID: 23385461]
  4. Pletzer, D., Lafon, C., Braun, Y., Kohler, T., Page, M. G., Mourez, M., Weingart, H.
    High-throughput screening of dipeptide utilization mediated by the ABC transporter DppBCDF and its substrate-binding proteins DppA1-A5 in Pseudomonas aeruginosa.
    PLoS ONE 9 : e111311 (2014). [PMID: 25338022]

[EC 7.4.2.9 created 2018]