EC 7.4.2.3 - Mitochondrial protein-transporting ATPase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 7.4.2.3

Names

Accepted name:
mitochondrial protein-transporting ATPase
Systematic name:
ATP phosphohydrolase (mitochondrial protein-importing)

Reaction

Comments:

A non-phosphorylated, non-ABC (ATP-binding cassette) ATPase involved in the transport of proteins or preproteins into mitochondria using the TIM protein complex. TIM is the protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor. Formerly EC 3.6.3.51.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0015450 , GO:0008566

References

  1. Bomer, U., Meijer, M., Maarse, A.C., Honlinger, A., Dekker, P.J., Pfanner, N. and Rassow, J.
    Multiple interactions of components mediating preprotein translocation across the inner mitochondrial membrane.
    EMBO J. 16 : 2205-2216 (1997). [PMID: 9171336]
  2. Berthold, J., Bauer, M.F., Schneider, H.C., Klaus, C., Dietmeier, K., Neupert, W. and Brunner, M.
    The MIM complex mediates preprotein translocation across the mitochondrial inner membrane and couples it to the mt-Hsp70/ATP-driving system.
    Cell 81 : 1085-1093 (1995). [PMID: 7600576]
  3. Voos, W., Martin, H., Krimmer, T. and Pfanner, N.
    Mechanisms of protein translocation into mitochondria.
    Biochim. Biophys. Acta 1422 : 235-254 (1999). [PMID: 10548718]

[EC 7.4.2.3 created 2000 as EC 3.6.3.51, transferred 2018 to EC 7.4.2.3]