EC 7.4.2.13 - ABC-type tyrosine transporter

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IntEnz Enzyme Nomenclature
EC 7.4.2.13

Names

Accepted name:
ABC-type tyrosine transporter
Systematic name:
ATP phosphohydrolase (ABC-type, L-tyrosine-importing)

Reaction

Comments:

An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, found in Clostridioides, interacts with an extracytoplasmic substrate binding lipoprotein and mediates the import of L-tyrosine. L-phenylalanine is also tranported however with lower efficiency.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Steglich, M., Hofmann, J. D., Helmecke, J., Sikorski, J., Sproer, C., Riedel, T., Bunk, B., Overmann, J., Neumann-Schaal, M., Nubel, U.
    Convergent Loss of ABC Transporter Genes From Clostridioides difficile Genomes Is Associated With Impaired Tyrosine Uptake and p-Cresol Production.
    Front Microbiol 9 : 901 (2018). [PMID: 29867812]

[EC 7.4.2.13 created 2019]