EC 7.4.2.12 - ABC-type cystine transporter

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IntEnz Enzyme Nomenclature
EC 7.4.2.12

Names

Accepted name:
ABC-type cystine transporter
Other names:
cystine transporting ATPase
cystine ABC transporter
Systematic name:
ATP phosphohydrolase (ABC-type, cystine-importing)

Reactions

Comments:

ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity import of trace cystine. The enzyme from Escherichia coli K-12 can import both isomers of cystine and a variety of related molecules including djenkolate, lanthionine, diaminopimelate and homocystine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Berger, E. A., Heppel, L. A.
    A binding protein involved in the transport of cystine and diaminopimelic acid in Escherichia coli.
    J. Biol. Chem. 247 : 7684-7694 (1972). [PMID: 4564569]
  2. Chonoles Imlay, K. R., Korshunov, S., Imlay, J. A.
    Physiological Roles and Adverse Effects of the Two Cystine Importers of Escherichia coli.
    J. Bacteriol. 197 : 3629-3644 (2015). [PMID: 26350134]

[EC 7.4.2.12 created 2019]