EC 7.3.2.6 - ABC-type tungstate transporter

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IntEnz Enzyme Nomenclature
EC 7.3.2.6

Names

Accepted name:
ABC-type tungstate transporter
Other names:
tungstate transporter
WtpABC
TupABC
tungstate-specific ABC transporter
tungstate-importing ATPase
Systematic name:
ATP phosphohydrolase (ABC-type, tungstate-importing)

Reaction

Comments:

An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, characterized from the archaeon Pyrococcus furiosus, the Gram-positive bacterium Eubacterium acidaminophilum and the Gram-negative bacterium Campylobacter jejuni, interacts with an extracytoplasmic substrate binding protein and mediates the import of tungstate into the cell for incorporation into tungsten-dependent enzymes. Formerly EC 3.6.3.55.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:1901238
UniProtKB/Swiss-Prot:

References

  1. Makdessi, K., Andreesen, J. R., Pich, A.
    Tungstate Uptake by a highly specific ABC transporter in Eubacterium acidaminophilum.
    J. Biol. Chem. 276 : 24557-24564 (2001). [PMID: 11292832]
  2. Bevers, L. E., Hagedoorn, P. L., Krijger, G. C., Hagen, W. R.
    Tungsten transport protein A (WtpA) in Pyrococcus furiosus: the first member of a new class of tungstate and molybdate transporters.
    J. Bacteriol. 188 : 6498-6505 (2006). [PMID: 16952940]
  3. Smart, J. P., Cliff, M. J., Kelly, D. J.
    A role for tungsten in the biology of Campylobacter jejuni: tungstate stimulates formate dehydrogenase activity and is transported via an ultra-high affinity ABC system distinct from the molybdate transporter.
    Mol. Microbiol. 74 : 742-757 (2009). [PMID: 19818021]

[EC 7.3.2.6 created 2013 as EC 3.6.3.55, transferred 2018 to EC 7.3.2.6]