EC 7.2.2.3 - P-type Na+ transporter

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IntEnz Enzyme Nomenclature
EC 7.2.2.3

Names

Accepted name:
P-type Na+ transporter
Other names:
sodium transport ATPase
Na+-exporting ATPase [ambiguous]
sodium-translocating P-type ATPase
Na+-transporting ATPase
sodium-exporting ATPase [ambiguous]
ENA1 (gene name)
Systematic name:
ATP phosphohydrolase (P-type, Na+-exporting)

Reaction

Cofactor

Comments:

A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme from yeast is involved in the efflux of Na+, with one ion being exported per ATP hydrolysed. Some forms can also export Li+ ions. cf. EC 7.2.2.1, Na+-transporting two-sector ATPase and EC 7.2.2.4, ABC-type Na+ transporter.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00139
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008554
UniProtKB/Swiss-Prot:

References

  1. Wieland, J., Nitsche, A.M., Strayle, J., Steiner, H. and Rudolph, H.K.
    The PMR2 gene cluster encodes functionally distinct isoforms of a putative Na+ pump in the yeast plasma membrane.
    EMBO J. 14 : 3870-3882 (1995). [PMID: 7664728]
  2. Catty, P., de Kerchove d'Exaerde, A. and Goffeau, A.
    The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPases.
    FEBS Lett. 409 : 325-332 (1997). [PMID: 9224683]
  3. Cheng, J., Guffanti, A.A. and Krulwich, T.A.
    A two-gene ABC-type transport system that extrudes Na+ in Bacillus subtilis is induced by ethanol or protonophore.
    Mol. Microbiol. 23 : 1107-1120 (1997). [PMID: 9106203]
  4. Saier, M.H., Jr.
    Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya.
    Adv. Microb. Physiol. 40 : 81-136 (1998). [PMID: 9889977]

[EC 7.2.2.3 created 2000, as EC 3.6.3.7, modified 2001, transferred 20018 to EC 7.2.2.3]