EC 7.2.2.18 - ABC-type ferric citrate transporter

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IntEnz Enzyme Nomenclature
EC 7.2.2.18

Names

Accepted name:
ABC-type ferric citrate transporter
Other names:
ferric citrate transporting ATPase
ferric citrate ABC transporter
fecBCDE (gene names)
Systematic name:
ATP phosphohydrolase (ABC-type, iron(III) dicitrate-importing)

Reaction

Comments:

An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme from Escherichia coli interacts with a periplasmic substrate binding protein and mediates the high affinity uptake of Fe3+-citrate in the form of a mononuclear (containing one iron(III) ion and two citrate molecules) or dinuclear (containing 2 iron(III) ions) complexes. Formerly EC 3.6.3.34.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Staudenmaier, H., Van Hove, B., Yaraghi, Z., Braun, V.
    Nucleotide sequences of the fecBCDE genes and locations of the proteins suggest a periplasmic-binding-protein-dependent transport mechanism for iron(III) dicitrate in Escherichia coli.
    J. Bacteriol. 171: 2626-2633 (1989). [PMID: 2651410]
  2. Banerjee, S., Paul, S., Nguyen, L. T., Chu, B. C., Vogel, H. J.
    FecB, a periplasmic ferric-citrate transporter from E. coli, can bind different forms of ferric-citrate as well as a wide variety of metal-free and metal-loaded tricarboxylic acids.
    Metallomics 8: 125-133 (2016). [PMID: 26600288]

[EC 7.2.2.18 created 2000 as EC 3.6.3.34, part transferred 2018 to EC 7.2.2.18]