EC 7.2.2.16 - ABC-type ferric hydroxamate transporter

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IntEnz Enzyme Nomenclature
EC 7.2.2.16

Names

Accepted name:
ABC-type ferric hydroxamate transporter
Other names:
iron(III) hydroxamate transporting ATPase
iron(III) hydroxamate ABC transporter
fhuCDB (gene names)
Systematic name:
ATP phosphohydrolase [ABC-type, iron(III) hydroxamate-importing]

Reaction

Comments:

An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the import of Fe3+-complexed hydroxamate siderophores such as coprogen, ferrichrome and the ferric hydroxamate antibiotic, albomycin. Formerly EC 3.6.3.34.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00185
Structural data: CSA , EC2PDB
Gene Ontology: GO:0015625 , GO:0015623
UniProtKB/Swiss-Prot:

References

  1. Koster, W.
    Iron(III) hydroxamate transport across the cytoplasmic membrane of Escherichia coli.
    Biol Met 4: 23-32 (1991). [PMID: 1830209]
  2. Speziali, C. D., Dale, S. E., Henderson, J. A., Vines, E. D., Heinrichs, D. E.
    Requirement of Staphylococcus aureus ATP-binding cassette-ATPase FhuC for iron-restricted growth and evidence that it functions with more than one iron transporter.
    J. Bacteriol. 188: 2048-2055 (2006). [PMID: 16513734]

[EC 7.2.2.16 created 2000 as EC 3.6.3.34, part transferred 2018 to EC 7.2.2.16]