EC - Na+/K+-exchanging ATPase

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IntEnz Enzyme Nomenclature


Accepted name:
Na+/K+-exchanging ATPase
Other names:
(Na+ + K+)-ATPase
(Na+ + K+)-activated ATPase
Na,K-activated ATPase
Na+,K+ pump
sodium pump
sodium/potassium-transporting ATPase
Systematic name:
ATP phosphohydrolase (P-type, Na+/K+-exchanging)




A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This is a plasma membrane enzyme, ubiquitous in animal cells, that catalyses the efflux of three Na+ and influx of two K+ per ATP hydrolysed. It is involved in generating the plasma membrane electrical potential.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00139 , PROSITE:PDOC00328
Structural data: CSA , EC2PDB
Gene Ontology: GO:0005391
UniProtKB/Swiss-Prot: (50) [show] [UniProt]


  1. Skou, J.C.
    The influence of some cations on an adenosinetriphosphatase from peripheral nerve.
    Biochim. Biophys. Acta 23 : 394-401 (1957). [PMID: 13412736]
  2. Post, R.L., Sen, A.K. and Rosenthal, A.S.
    A phosphorylated intermediate in adenosine triphosphate-dependent sodium and potassium transport across kidney membrane.
    J. Biol. Chem. 240 : 1437-1445 (1965). [PMID: 14284759]
  3. Skou, J.C.
    The energy-coupled exchange of Na+ for K+ across the cell membrane. The Na+,K+ pump.
    FEBS Lett. 268 : 314-324 (1990). [PMID: 2166689]
  4. Castillo, J. P., Rui, H., Basilio, D., Das, A., Roux, B., Latorre, R., Bezanilla, F., Holmgren, M.
    Mechanism of potassium ion uptake by the Na(+)/K(+)-ATPase.
    Nat Commun 6 : 7622 (2015). [PMID: 26205423]

[EC created 1984 EC, transferred 2000 to EC, modified 2001, transferred 2018 to EC]