EC 7.2.2.13 - Na+/K+-exchanging ATPase

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IntEnz Enzyme Nomenclature
EC 7.2.2.13

Names

Accepted name:
Na+/K+-exchanging ATPase
Other names:
(Na+ + K+)-ATPase
(Na+ + K+)-activated ATPase
Na,K-activated ATPase
Na,K-pump
Na+,K+ pump
Na+,K+-ATPase
sodium pump
sodium/potassium-transporting ATPase
Na+/K+-ATPase
Systematic name:
ATP phosphohydrolase (P-type, Na+/K+-exchanging)

Reaction

Cofactor

Comments:

A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This is a plasma membrane enzyme, ubiquitous in animal cells, that catalyses the efflux of three Na+ and influx of two K+ per ATP hydrolysed. It is involved in generating the plasma membrane electrical potential.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00139 , PROSITE:PDOC00328
Structural data: CSA , EC2PDB
Gene Ontology: GO:0005391
UniProtKB/Swiss-Prot: (37) [show] [UniProt]

References

  1. Skou, J.C.
    The influence of some cations on an adenosinetriphosphatase from peripheral nerve.
    Biochim. Biophys. Acta 23: 394-401 (1957). [PMID: 13412736]
  2. Post, R.L., Sen, A.K. and Rosenthal, A.S.
    A phosphorylated intermediate in adenosine triphosphate-dependent sodium and potassium transport across kidney membrane.
    J. Biol. Chem. 240: 1437-1445 (1965). [PMID: 14284759]
  3. Skou, J.C.
    The energy-coupled exchange of Na+ for K+ across the cell membrane. The Na+,K+ pump.
    FEBS Lett. 268: 314-324 (1990). [PMID: 2166689]
  4. Castillo, J. P., Rui, H., Basilio, D., Das, A., Roux, B., Latorre, R., Bezanilla, F., Holmgren, M.
    Mechanism of potassium ion uptake by the Na(+)/K(+)-ATPase.
    Nat Commun 6: 7622 (2015). [PMID: 26205423]

[EC 7.2.2.13 created 1984 EC 3.6.1.37, transferred 2000 to EC 3.6.3.9, modified 2001, transferred 2018 to EC 7.2.2.13]