EC - Ferredoxin—NAD+ oxidoreductase (Na+-transporting)

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IntEnz Enzyme Nomenclature


Accepted name:
ferredoxin—NAD+ oxidoreductase (Na+-transporting)
Other names:
Rnf complex [ambiguous]
Na+-translocating ferredoxin:NAD+ oxidoreductase
Systematic name:
ferredoxin:NAD+ oxidoreductase (Na+-transporting)




This iron-sulfur and flavin-containing electron transport complex, isolated from the bacterium Acetobacterium woodii, couples the energy from reduction of NAD+ by ferredoxin to pumping sodium ions out of the cell, generating a gradient across the cytoplasmic membrane.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Biegel, E., Schmidt, S., Muller, V.
    Genetic, immunological and biochemical evidence for a Rnf complex in the acetogen Acetobacterium woodii.
    Environ. Microbiol. 11 : 1438-1443 (2009). [PMID: 19222539]
  2. Biegel, E., Muller, V.
    Bacterial Na+-translocating ferredoxin:NAD+ oxidoreductase.
    Proc. Natl. Acad. Sci. U.S.A. 107 : 18138-18142 (2010). [PMID: 20921383]
  3. Hess, V., Schuchmann, K., Muller, V.
    The ferredoxin:NAD+ oxidoreductase (Rnf) from the acetogen Acetobacterium woodii requires Na+ and is reversibly coupled to the membrane potential.
    J. Biol. Chem. 288 : 31496-31502 (2013). [PMID: 24045950]

[EC created 2015 as EC, transferred 2018 to EC]