EC - P-type H+-exporting transporter

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IntEnz Enzyme Nomenclature


Accepted name:
P-type H+-exporting transporter
Other names:
ATP phosphohydrolase [ambiguous]
proton-translocating ATPase
yeast plasma membrane ATPase
yeast plasma membrane H+-ATPase
proton transport ATPase
proton-translocating P-type ATPase
H+-transporting ATPase
Systematic name:
ATP phosphohydrolase (P-type, H+-exporting)




A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme occurs in protozoa, fungi and plants, and generates an electrochemical potential gradient of protons across the plasma membrane. Formerly EC and EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00139
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008553
UniProtKB/Swiss-Prot: (33) [show] [UniProt]


  1. Goffeau, A. and Slayman, C.
    The proton-translocating ATPase of the fungal plasma membrane.
    Biochim. Biophys. Acta 639: 197-223 (1981). [PMID: 6461354]
  2. Serrano, R., Kielland-Brandt, M.C. and Fink, G.R.
    Yeast plasma membrane ATPase is essential for growth and has homology with (Na++K+)-, K+-and Ca2+-ATPases.
    Nature 319: 689-693 (1986). [PMID: 3005867]
  3. Serrano, R. and Portillo, F.
    Catalytic and regulatory sites of yeast plasma membrane H+-ATPase studied by directed mutagenesis.
    Biochim. Biophys. Acta 1018: 195-199 (1990). [PMID: 2144186]
  4. Perlin, D. S., San Francisco, M. J., Slayman, C. W., Rosen, B. P.
    H+/ATP stoichiometry of proton pumps from Neurospora crassa and Escherichia coli.
    Arch. Biochem. Biophys. 248: 53-61 (1986). [PMID: 2425739]
  5. Venema, K., Palmgren, M. G.
    Metabolic modulation of transport coupling ratio in yeast plasma membrane H(+)-ATPase.
    J. Biol. Chem. 270: 19659-19667 (1995). [PMID: 7642655]

[EC created 1984 as EC, transferred 2000 to EC, transferred 2018 to EC]