EC - Magnesium chelatase

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IntEnz Enzyme Nomenclature


Accepted name:
magnesium chelatase
Other names:
Mg-protoporphyrin IX magnesio-lyase
magnesium-protoporphyrin IX chelatase
magnesium-protoporphyrin chelatase
protoporphyrin IX Mg-chelatase
protoporphyrin IX magnesium-chelatase
Systematic name:
Mg-protoporphyrin IX magnesium-lyase



This is the first committed step of chlorophyll biosynthesis and is a branchpoint of two major routes in the tetrapyrrole pathway. The magnesium is probably bound to protoporphyrin IX-21,23-diylium.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0016851
CAS Registry Number: 9074-88-8
UniProtKB/Swiss-Prot: (46) [show] [UniProt]


  1. Walker, C.J. and Weinstein, J.D.
    In vitro assay of the chlorophyll biosynthetic enzyme Mg-chelatase: resolution of the activity into soluble and membrane-bound fractions.
    Proc. Natl. Acad. Sci. USA 88 : 5789-5793 (1991). [PMID: 11607197]
  2. Walker, C.J. and Willows, R.D.
    Mechanism and regulation of Mg-chelatase.
    Biochem. J. 327 : 321-333 (1997). [PMID: 9359397]
  3. Fodje, M.N., Hansson, A., Hansson, M., Olsen, J.G., Gough, S., Willows, R.D. and Al-Karadaghi, S.
    Interplay between an AAA module and an integrin I domain may regulate the function of magnesium chelatase.
    J. Mol. Biol. 311 : 111-122 (2001). [PMID: 11469861]

[EC created 2003]