IntEnz

EC 6.6.1.1 - Magnesium chelatase

IntEnz Enzyme Nomenclature
EC 6.6.1.1

Names

Reaction

• 13961 [IUBMB]
  ATP

  ATP

  Name origin: UniProt - CHECKED (C)

  CHEBI:30616

  Formula: C10H12N5O13P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  +

  H₂O

  H2O

  Name origin: UniProt - CHECKED (C)

  CHEBI:15377

  Formula: H2O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  Mg²⁺

  Mg(2+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:18420

  Formula: Mg
  Charge: 2

  ChEBI compound status: CHECKED (C)

  

  +

  protoporphyrin IX

  protoporphyrin IX

  Name origin: UniProt - CHECKED (C)

  CHEBI:57306

  Formula: C34H32N4O4
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  =

  ADP

  ADP

  Name origin: UniProt - CHECKED (C)

  CHEBI:456216

  Formula: C10H12N5O10P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  3

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  Mg-protoporphyrin IX

  Mg-protoporphyrin IX

  Name origin: UniProt - CHECKED (C)

  CHEBI:60492

  Formula: C34H30MgN4O4
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  phosphate

  phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:43474

  Formula: HO4P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

Comments:

This is the first committed step of chlorophyll biosynthesis and is a branchpoint of two major routes in the tetrapyrrole pathway. The magnesium is probably bound to protoporphyrin IX-21,23-diylium.

Links to other databases

References

1. Walker, C.J. and Weinstein, J.D.
   In vitro assay of the chlorophyll biosynthetic enzyme Mg-chelatase: resolution of the activity into soluble and membrane-bound fractions.
   Proc. Natl. Acad. Sci. USA 88: 5789-5793 (1991). [PMID: 11607197]
2. Walker, C.J. and Willows, R.D.
   Mechanism and regulation of Mg-chelatase.
   Biochem. J. 327: 321-333 (1997). [PMID: 9359397]
3. Fodje, M.N., Hansson, A., Hansson, M., Olsen, J.G., Gough, S., Willows, R.D. and Al-Karadaghi, S.
   Interplay between an AAA module and an integrin I domain may regulate the function of magnesium chelatase.
   J. Mol. Biol. 311: 111-122 (2001). [PMID: 11469861]

[EC 6.6.1.1 created 2003]