EC 6.6.1.1 - Magnesium chelatase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 6.6.1.1
Names
Accepted name:
magnesium chelatase
Other
names:
Mg-chelatase
Mg-protoporphyrin IX magnesio-lyase
magnesium-chelatase
magnesium-protoporphyrin IX chelatase
magnesium-protoporphyrin chelatase
protoporphyrin IX Mg-chelatase
protoporphyrin IX magnesium-chelatase
Mg-protoporphyrin IX magnesio-lyase
magnesium-chelatase
magnesium-protoporphyrin IX chelatase
magnesium-protoporphyrin chelatase
protoporphyrin IX Mg-chelatase
protoporphyrin IX magnesium-chelatase
Systematic name:
Mg-protoporphyrin IX magnesium-lyase
Reaction
- ATP + protoporphyrin IX + Mg2+ + H2O = ADP + phosphate + Mg-protoporphyrin IX + 2 H+
Comments:
This is the first committed step of chlorophyll biosynthesis and is a branchpoint of two major routes in the tetrapyrrole pathway. The magnesium is probably bound to protoporphyrin IX-21,23-diylium.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Gene Ontology:
GO:0016851
CAS Registry Number:
9074-88-8
References
-
In vitro assay of the chlorophyll biosynthetic enzyme Mg-chelatase: resolution of the activity into soluble and membrane-bound fractions.Proc. Natl. Acad. Sci. USA 88 : 5789-5793 (1991). [PMID: 11607197]
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Mechanism and regulation of Mg-chelatase.Biochem. J. 327 : 321-333 (1997). [PMID: 9359397]
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Interplay between an AAA module and an integrin I domain may regulate the function of magnesium chelatase.J. Mol. Biol. 311 : 111-122 (2001). [PMID: 11469861]
[EC 6.6.1.1 created 2003]