EC - Cyclic 2,3-diphosphoglycerate synthase

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IntEnz Enzyme Nomenclature


Accepted name:
cyclic 2,3-diphosphoglycerate synthase
Systematic name:
(2R)-2,3-bisphosphoglycerate ligase (cyclizing)



The enzyme is present in a number of methanogenic archaeal genera that accumulate cyclic 2,3-bisphosphoglycerate as a thermoprotectant. Activity is stimulated by potassium ions.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (13) [show] [UniProt]


  1. Lehmacher, A., Vogt, A. B., Hensel, R.
    Biosynthesis of cyclic 2,3-diphosphoglycerate. Isolation and characterization of 2-phosphoglycerate kinase and cyclic 2,3-diphosphoglycerate synthetase from Methanothermus fervidus.
    FEBS Lett. 272 : 94-98 (1990). [PMID: 2226838]
  2. Matussek, K., Moritz, P., Brunner, N., Eckerskorn, C., Hensel, R.
    Cloning, sequencing, and expression of the gene encoding cyclic 2, 3-diphosphoglycerate synthetase, the key enzyme of cyclic 2, 3-diphosphoglycerate metabolism in Methanothermus fervidus.
    J. Bacteriol. 180 : 5997-6004 (1998). [PMID: 9811660]

[EC created 2020]