EC 6.4.1.7 - 2-oxoglutarate carboxylase

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IntEnz Enzyme Nomenclature
EC 6.4.1.7

Names

Accepted name:
2-oxoglutarate carboxylase
Other names:
oxalosuccinate synthetase
carboxylating factor for ICDH [incorrect]
CFI
OGC
Systematic name:
-

Reaction

Cofactors

Comments:

A biotin-containing enzyme that requires Mg2+ for activity. It was originally thought [1] that this enzyme was a promoting factor for the carboxylation of 2-oxoglutarate by EC 1.1.1.41, isocitrate dehydrogenase (NAD+), but this has since been disproved [2]. The product of the reaction is unstable and is quickly converted into isocitrate by the action of EC 1.1.1.41 [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00676 , PROSITE:PDOC50975
Structural data: CSA , EC2PDB
Gene Ontology: GO:0034029
UniProtKB/Swiss-Prot:

References

  1. Aoshima, M., Ishii, M. and Igarashi, Y.
    A novel biotin protein required for reductive carboxylation of 2-oxoglutarate by isocitrate dehydrogenase in Hydrogenobacter thermophilus TK-6.
    Mol. Microbiol. 51: 791-798 (2004). [PMID: 14731279]
  2. Aoshima, M. and Igarashi, Y.
    A novel oxalosuccinate-forming enzyme involved in the reductive carboxylation of 2-oxoglutarate in Hydrogenobacter thermophilus TK-6.
    Mol. Microbiol. 62: 748-759 (2006). [PMID: 17076668]

[EC 6.4.1.7 created 2006]