EC - Propionyl-CoA carboxylase

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IntEnz Enzyme Nomenclature


Accepted name:
propionyl-CoA carboxylase
Other names:
propionyl coenzyme A carboxylase
Systematic name:
propanoyl-CoA:carbon-dioxide ligase (ADP-forming)




A biotinyl-protein. Also carboxylates butanoyl-CoA and catalyses transcarboxylation.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00167 , PROSITE:PDOC00676 , PROSITE:PDOC50975 , PROSITE:PDOC50979 , PROSITE:PDOC50980
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004658
CAS Registry Number: 9023-94-3
UniProtKB/Swiss-Prot: (24) [show] [UniProt]


  1. Kaziro, Y., Ochoa, S., Warner, R.C. and Chen, J.-Y.
    Metabolism of propionic acid in animal tissues. VIII. Crystalline propionyl carboxylase.
    J. Biol. Chem. 236: 1917-1923 (1961). [PMID: 13752080]
  2. Lane, M.D., Halenz, D.R., Kosow, D.P. and Hegre, C.S.
    Further studies on mitochondrial propionyl carboxylase.
    J. Biol. Chem. 235: 3082-3086 (1960). [PMID: 13758723]
  3. Meyer, H., Nevaldine, B. and Meyer, F.
    Acyl-coenzyme A carboxylase of the free-living nematode Turbatrix aceti. 1. Its isolation and molecular characteristics.
    Biochemistry 17: 1822-1827 (1978). [PMID: 656363]
  4. Moss, J. and Lane, M.D.
    The biotin-dependent enzymes.
    Adv. Enzymol. Relat. Areas Mol. Biol. 35: 321-442 (1971). [PMID: 4150153]
  5. Vagelos, P.
    Regulation of fatty acid biosynthesis.
    Curr. Top. Cell. Regul. 4: 119-166 (1971).

[EC created 1961, modified 1983]