EC - Pyruvate carboxylase

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IntEnz Enzyme Nomenclature


Accepted name:
pyruvate carboxylase
Other name:
pyruvic carboxylase
Systematic name:
pyruvate:carbon-dioxide ligase (ADP-forming)




A biotinyl-protein containing manganese (animal tissues) or zinc (yeast). The animal enzyme requires acetyl-CoA.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00167 , PROSITE:PDOC00676 , PROSITE:PDOC50975 , PROSITE:PDOC50979 , PROSITE:PDOC50991
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004736
CAS Registry Number: 9014-19-1
UniProtKB/Swiss-Prot: (19) [show] [UniProt]


  1. McClure, W.R., Lardy, H.A. and Kneifel, H.P.
    Rat liver pyruvate carboxylase. I. Preparation, properties, and cation specificity.
    J. Biol. Chem. 246: 3569-3578 (1971). [PMID: 5578910]
  2. Scrutton, M.C., Young, M.R. and Utter, M.F.
    Pyruvate carboxylase from baker's yeast. The presence of bound zinc.
    J. Biol. Chem. 245: 6220-6227 (1970). [PMID: 5484476]
  3. Seubert, W. and Remberger, U.
    Renigung und Wirkungsweise der Pyruvatcarboxylase aus Pseudomonas citronellolis.
    Biochem. Z. 334: 401-414 (1961).
  4. Utter, M.F. and Keech, D.B.
    Pyruvate carboxylase. I. Nature of the reaction.
    J. Biol. Chem. 238: 2603-2608 (1963). [PMID: 14063279]

[EC created 1961]