EC - Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)

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IntEnz Enzyme Nomenclature


Accepted name:
hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
Other name:
Systematic name:
hydrogenobyrinic-acid:L-glutamine amido-ligase (AMP-forming)



This enzyme, which participates in the aerobic (late cobalt insertion) cobalamin biosynthesis pathway, generates hydrogenobyrinate a,c-diamide, the substrate required by EC which adds cobalt to the macrocycle. The equivalent reaction in the anaerobic cobalamin biosynthesis pathway is catalysed by EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0043802
CAS Registry Number: 132053-22-6
UniProtKB/Swiss-Prot: (17) [show] [UniProt]


  1. Debussche, L., Thibaut, D., Cameron, B., Crouzet, J. and Blanche, F.
    Purification and characterization of cobyrinic acid a,c-diamide synthase from Pseudomonas denitrificans.
    J. Bacteriol. 172 : 6239-6244 (1990). [PMID: 2172209]
  2. Warren, M.J., Raux, E., Schubert, H.L. and Escalante-Semerena, J.C.
    The biosynthesis of adenosylcobalamin (vitamin B12).
    Nat. Prod. Rep. 19 : 390-412 (2002). [PMID: 12195810]

[EC created 2004]