EC 6 - Ligases
EC 6.3 - Forming carbon-nitrogen bonds
EC 6.3.5 - Carbon—nitrogen ligases with glutamine as amido-N-donor
EC 6.3.5.2 - GMP synthase (glutamine-hydrolysing)
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 6.3.5.2
Names
Accepted name:
GMP synthase (glutamine-hydrolysing)
Other
names:
GMP synthetase (glutamine-hydrolysing)
guanosine 5'-monophosphate synthetase
guanosine monophosphate synthetase (glutamine-hydrolyzing)
guanylate synthetase (glutamine-hydrolyzing)
xanthosine 5'-phosphate amidotransferase
guanosine 5'-monophosphate synthetase
guanosine monophosphate synthetase (glutamine-hydrolyzing)
guanylate synthetase (glutamine-hydrolyzing)
xanthosine 5'-phosphate amidotransferase
Systematic name:
xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)
Reactions
- (1) ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate
- (1a) L-glutamine + H2O = L-glutamate + NH4+
- (1b) ATP + XMP + NH4+ = AMP + diphosphate + GMP
Comments:
Involved in the de novo biosynthesis of guanosine nucleotides. An N-terminal glutaminase domain binds L-glutamine and generates ammonia, which is transferred by a substrate-protective tunnel to the ATP-pyrophosphatase domain. The enzyme can catalyse the second reaction alone in the presence of ammonia. Formerly EC 6.3.4.1.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
ERGO
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Protein domains and families:
PROSITE:PDOC00405
Gene Ontology:
GO:0003922
CAS Registry Number:
37318-71-1
GUAA-2_CAEEL
GUAA-2_HUMAN
GUAA-3_CAEEL
GUAA1_BACTN
GUAA2_BACTN
GUAAA_ARCFU
GUAAA_HALMA
GUAAA_HALSA
GUAAA_HALWD
GUAAA_IGNH4
GUAAA_META3
GUAAA_METAC
GUAAA_METAR
GUAAA_METB6
GUAAA_METBF
GUAAA_METBU
GUAAA_METHJ
GUAAA_METJA
GUAAA_METKA
GUAAA_METM5
GUAAA_METM6
GUAAA_METM7
GUAAA_METMA
GUAAA_METMJ
GUAAA_METMP
GUAAA_METS3
GUAAA_METST
GUAAA_METTH
GUAAA_METTP
GUAAA_METVS
GUAAA_NATPD
GUAAA_PICTO
GUAAA_PYRAB
GUAAA_PYRFU
GUAAA_PYRHO
GUAAA_SACS2
GUAAA_SULAC
GUAAA_SULTO
GUAAA_THEAC
GUAAA_THEKO
GUAAA_THEVO
GUAAB_ARCFU
GUAAB_HALLT
GUAAB_HALMA
GUAAB_HALS3
GUAAB_HALSA
GUAAB_METAC
GUAAB_METAR
GUAAB_METB6
GUAAB_METBF
GUAAB_METBU
GUAAB_METJA
GUAAB_METKA
GUAAB_METM7
GUAAB_METMA
GUAAB_METMJ
GUAAB_METMP
GUAAB_METPE
GUAAB_METTH
GUAAB_METVS
GUAAB_NATPD
GUAAB_PICTO
GUAAB_PYRAB
GUAAB_PYRFU
GUAAB_PYRHO
GUAAB_SACS2
GUAAB_SULIA
GUAAB_SULIK
GUAAB_SULIL
GUAAB_SULIM
GUAAB_SULIN
GUAAB_SULIY
GUAAB_SULTO
GUAAB_THEAC
GUAAB_THEKO
GUAAB_THEVO
GUAA_ACET2
GUAA_ACIAD
GUAA_ACTP2
GUAA_ACTP7
GUAA_ACTPJ
GUAA_ACTSZ
GUAA_AERHH
GUAA_AERPE
GUAA_AERS4
GUAA_AFIC5
GUAA_AGARV
GUAA_AGRFC
GUAA_AGRRK
GUAA_AGRVS
GUAA_ALCBS
GUAA_ALIB4
GUAA_ALIF1
GUAA_ALIFM
GUAA_ALISL
GUAA_ALKEH
GUAA_ALKHC
GUAA_ALKMQ
GUAA_ALTMD
GUAA_ANAMF
GUAA_ANAMM
GUAA_AQUAE
GUAA_AROAE
GUAA_ASHGO
GUAA_ASPFU
GUAA_ASPOR
GUAA_AZOSB
GUAA_BACAA
GUAA_BACAC
GUAA_BACAH
GUAA_BACAN
GUAA_BACC0
GUAA_BACC1
GUAA_BACC2
GUAA_BACC3
GUAA_BACC4
GUAA_BACCN
GUAA_BACCR
GUAA_BACCZ
GUAA_BACFN
GUAA_BACFR
GUAA_BACHK
GUAA_BACLD
GUAA_BACMK
GUAA_BACP2
GUAA_BACSK
GUAA_BACSU
GUAA_BACVZ
GUAA_BARBK
GUAA_BARHE
GUAA_BARQU
GUAA_BAUCH
GUAA_BDEBA
GUAA_BIFLO
GUAA_BLOFL
GUAA_BLOPB
GUAA_BORA1
GUAA_BORBN
GUAA_BORBP
GUAA_BORBR
GUAA_BORBU
GUAA_BORPA
GUAA_BORPD
GUAA_BORPE
GUAA_BRADU
GUAA_BRAHW
GUAA_BRASO
GUAA_BRUA1
GUAA_BRUA2
GUAA_BRUAB
GUAA_BRUC2
GUAA_BRUMB
GUAA_BRUME
GUAA_BRUO2
GUAA_BRUSI
GUAA_BRUSU
GUAA_BURA4
GUAA_BURCA
GUAA_BURCC
GUAA_BURCH
GUAA_BURCJ
GUAA_BURCM
GUAA_BURL3
GUAA_BURM1
GUAA_BURM7
GUAA_BURM9
GUAA_BURMA
GUAA_BURMS
GUAA_BURP0
GUAA_BURP1
GUAA_BURP6
GUAA_BURPS
GUAA_BURVG
GUAA_CAEEL
GUAA_CALBD
GUAA_CALS4
GUAA_CALS8
GUAA_CAMFF
GUAA_CAMHC
GUAA_CAMJ8
GUAA_CAMJD
GUAA_CAMJE
GUAA_CAMJJ
GUAA_CAMJR
GUAA_CAMLR
GUAA_CANAL
GUAA_CANGA
GUAA_CARHZ
GUAA_CAUVC
GUAA_CAUVN
GUAA_CELJU
GUAA_CERS4
GUAA_CERS5
GUAA_CHLCH
GUAA_CHLCV
GUAA_CHLFF
GUAA_CHLL2
GUAA_CHLL3
GUAA_CHLMU
GUAA_CHLPB
GUAA_CHLPD
GUAA_CHLPM
GUAA_CHLPN
GUAA_CHLT3
GUAA_CHLTE
GUAA_CHRVO
GUAA_CITK8
GUAA_CLOAB
GUAA_CLOB1
GUAA_CLOB6
GUAA_CLOB8
GUAA_CLOBA
GUAA_CLOBB
GUAA_CLOBH
GUAA_CLOBJ
GUAA_CLOBK
GUAA_CLOBL
GUAA_CLOBM
GUAA_CLOD6
GUAA_CLOK1
GUAA_CLOK5
GUAA_CLONN
GUAA_CLOPE
GUAA_CLOTE
GUAA_COLP3
GUAA_CORAM
GUAA_CORDI
GUAA_COREF
GUAA_CORGB
GUAA_CORGL
GUAA_CORJK
GUAA_COXB1
GUAA_COXB2
GUAA_COXBN
GUAA_COXBR
GUAA_COXBU
GUAA_CROS5
GUAA_CROS8
GUAA_CUPMC
GUAA_CUPNH
GUAA_CUPPJ
GUAA_CUPTR
GUAA_CUTAK
GUAA_CYTH3
GUAA_DEBHA
GUAA_DECAR
GUAA_DEHM1
GUAA_DEHMC
GUAA_DEIDV
GUAA_DEIGD
GUAA_DEIRA
GUAA_DESAG
GUAA_DESMR
GUAA_DESPS
GUAA_DESVH
GUAA_DESVM
GUAA_DESVV
GUAA_DICDI
GUAA_DINSH
GUAA_ECO24
GUAA_ECO27
GUAA_ECO45
GUAA_ECO55
GUAA_ECO57
GUAA_ECO5E
GUAA_ECO7I
GUAA_ECO81
GUAA_ECO8A
GUAA_ECOBW
GUAA_ECODH
GUAA_ECOHS
GUAA_ECOK1
GUAA_ECOL5
GUAA_ECOL6
GUAA_ECOLC
GUAA_ECOLI
GUAA_ECOLU
GUAA_ECOSE
GUAA_ECOSM
GUAA_ECOUT
GUAA_EDWI9
GUAA_EHRCJ
GUAA_EHRCR
GUAA_EHRRG
GUAA_EHRRW
GUAA_ELUMP
GUAA_EMENI
GUAA_ENT38
GUAA_ENTFA
GUAA_ESCF3
GUAA_EXIS2
GUAA_FINM2
GUAA_FLAJ1
GUAA_FLAPJ
GUAA_FRAP2
GUAA_FRASN
GUAA_FRAT1
GUAA_FRATF
GUAA_FRATH
GUAA_FRATM
GUAA_FRATN
GUAA_FRATO
GUAA_FRATT
GUAA_FRATW
GUAA_FRUSA
GUAA_FUSNN
GUAA_GEMAT
GUAA_GEODF
GUAA_GEOKA
GUAA_GEOMG
GUAA_GEOSL
GUAA_GIBZE
GUAA_GLOC7
GUAA_GLOVI
GUAA_GLUOX
GUAA_GRAFK
GUAA_HAEDU
GUAA_HAEI8
GUAA_HAEIE
GUAA_HAEIG
GUAA_HAEIN
GUAA_HAEPS
GUAA_HAES1
GUAA_HAHCH
GUAA_HALOH
GUAA_HAMD5
GUAA_HELAH
GUAA_HELHP
GUAA_HELMI
GUAA_HELP2
GUAA_HELPG
GUAA_HELPH
GUAA_HELPJ
GUAA_HELPS
GUAA_HELPY
GUAA_HERAR
GUAA_HISS2
GUAA_HUMAN
GUAA_HYDCU
GUAA_IDILO
GUAA_JANMA
GUAA_KLEP3
GUAA_KLEP7
GUAA_KLULA
GUAA_LACAC
GUAA_LACCB
GUAA_LACDA
GUAA_LACDB
GUAA_LACE2
GUAA_LACGA
GUAA_LACJO
GUAA_LACLA
GUAA_LACLM
GUAA_LACLS
GUAA_LACP3
GUAA_LACPL
GUAA_LACRH
GUAA_LATSS
GUAA_LEGPA
GUAA_LEGPC
GUAA_LEGPH
GUAA_LEGPL
GUAA_LEIXX
GUAA_LEPIC
GUAA_LEPIN
GUAA_LIGS1
GUAA_LIMRD
GUAA_LIMRJ
GUAA_LISIN
GUAA_LISMF
GUAA_LISMO
GUAA_LISW6
GUAA_MACCJ
GUAA_MANSM
GUAA_MARMS
GUAA_MARN8
GUAA_MARSD
GUAA_MESFL
GUAA_METCA
GUAA_METFK
GUAA_METPP
GUAA_MICLC
GUAA_MOOTA
GUAA_MOUSE
GUAA_MYCBO
GUAA_MYCBP
GUAA_MYCBT
GUAA_MYCLB
GUAA_MYCLE
GUAA_MYCMM
GUAA_MYCPA
GUAA_MYCPE
GUAA_MYCTA
GUAA_MYCTO
GUAA_MYCTU
GUAA_NATTJ
GUAA_NEIG1
GUAA_NEIG2
GUAA_NEIM0
GUAA_NEIMA
GUAA_NEIMB
GUAA_NEIMF
GUAA_NITEC
GUAA_NITEU
GUAA_NITHX
GUAA_NITMU
GUAA_NITOC
GUAA_NITSB
GUAA_NITWN
GUAA_NOCFA
GUAA_NOSP7
GUAA_NOSS1
GUAA_OCEIH
GUAA_OPITP
GUAA_PARD8
GUAA_PARMW
GUAA_PARP8
GUAA_PARPJ
GUAA_PARXL
GUAA_PASMU
GUAA_PECAS
GUAA_PECCP
GUAA_PEDPA
GUAA_PELPB
GUAA_PELPD
GUAA_PELUB
GUAA_PETMO
GUAA_PHANO
GUAA_PHEZH
GUAA_PHOLL
GUAA_PHOPR
GUAA_PHOV8
GUAA_POLAQ
GUAA_POLNS
GUAA_PONAB
GUAA_PORG3
GUAA_PORGI
GUAA_PROM0
GUAA_PROM1
GUAA_PROM2
GUAA_PROM3
GUAA_PROM5
GUAA_PROM9
GUAA_PROMA
GUAA_PROMH
GUAA_PROMM
GUAA_PROMP
GUAA_PROMS
GUAA_PROMT
GUAA_PSE14
GUAA_PSEA6
GUAA_PSEA8
GUAA_PSEAB
GUAA_PSEAE
GUAA_PSEE4
GUAA_PSEF5
GUAA_PSEFS
GUAA_PSEMY
GUAA_PSEP1
GUAA_PSEPF
GUAA_PSEPG
GUAA_PSEPK
GUAA_PSEPW
GUAA_PSESM
GUAA_PSET1
GUAA_PSEU2
GUAA_PSYA2
GUAA_PSYIN
GUAA_PYRAE
GUAA_RALPJ
GUAA_RALSO
GUAA_RAT
GUAA_RHIE6
GUAA_RHIEC
GUAA_RHIL3
GUAA_RHILO
GUAA_RHILW
GUAA_RHIME
GUAA_RHOBA
GUAA_RHOFT
GUAA_RHOP2
GUAA_RHOPA
GUAA_RHOPB
GUAA_RHORT
GUAA_RHOS1
GUAA_RHOSK
GUAA_RIPO1
GUAA_ROSDO
GUAA_RUEPO
GUAA_RUEST
GUAA_RUMCH
GUAA_RUTMC
GUAA_SALA4
GUAA_SALAR
GUAA_SALCH
GUAA_SALDC
GUAA_SALEP
GUAA_SALG2
GUAA_SALHS
GUAA_SALNS
GUAA_SALPA
GUAA_SALPB
GUAA_SALPC
GUAA_SALPK
GUAA_SALRD
GUAA_SALSV
GUAA_SALTI
GUAA_SALTY
GUAA_SCHPO
GUAA_SERP5
GUAA_SHEAM
GUAA_SHEB2
GUAA_SHEB5
GUAA_SHEB8
GUAA_SHEB9
GUAA_SHEDO
GUAA_SHEFN
GUAA_SHEHH
GUAA_SHELP
GUAA_SHEON
GUAA_SHEPA
GUAA_SHEPC
GUAA_SHEPW
GUAA_SHESA
GUAA_SHESH
GUAA_SHESM
GUAA_SHESR
GUAA_SHESW
GUAA_SHEWM
GUAA_SHIB3
GUAA_SHIBS
GUAA_SHIDS
GUAA_SHIF8
GUAA_SHIFL
GUAA_SHISS
GUAA_SINFN
GUAA_SINMW
GUAA_SODGM
GUAA_SPIKU
GUAA_STAA1
GUAA_STAA2
GUAA_STAA3
GUAA_STAA8
GUAA_STAA9
GUAA_STAAB
GUAA_STAAC
GUAA_STAAE
GUAA_STAAM
GUAA_STAAN
GUAA_STAAR
GUAA_STAAS
GUAA_STAAT
GUAA_STAAW
GUAA_STACT
GUAA_STAEQ
GUAA_STAES
GUAA_STAHJ
GUAA_STAS1
GUAA_STRA1
GUAA_STRA3
GUAA_STRA5
GUAA_STRAW
GUAA_STRCO
GUAA_STRE4
GUAA_STRM5
GUAA_STRMK
GUAA_STRMU
GUAA_STRP1
GUAA_STRP2
GUAA_STRP3
GUAA_STRP4
GUAA_STRP6
GUAA_STRP7
GUAA_STRP8
GUAA_STRPB
GUAA_STRPC
GUAA_STRPD
GUAA_STRPF
GUAA_STRPG
GUAA_STRPI
GUAA_STRPJ
GUAA_STRPM
GUAA_STRPN
GUAA_STRPQ
GUAA_STRPS
GUAA_STRPZ
GUAA_STRR6
GUAA_STRS7
GUAA_STRT1
GUAA_STRT2
GUAA_STRU0
GUAA_STRZJ
GUAA_STRZP
GUAA_STRZT
GUAA_SULDN
GUAA_SULNB
GUAA_SYMTH
GUAA_SYNC1
GUAA_SYNP2
GUAA_SYNP6
GUAA_SYNS3
GUAA_SYNS9
GUAA_SYNSC
GUAA_SYNWW
GUAA_SYNY3
GUAA_TERTT
GUAA_THEAB
GUAA_THEFY
GUAA_THEM4
GUAA_THEMA
GUAA_THEP1
GUAA_THERP
GUAA_THESQ
GUAA_THET2
GUAA_THET8
GUAA_THEVB
GUAA_THIDA
GUAA_TOLAT
GUAA_TREDE
GUAA_TRIV2
GUAA_TROW8
GUAA_TROWT
GUAA_USTMA
GUAA_VESOH
GUAA_VIBA3
GUAA_VIBC3
GUAA_VIBCB
GUAA_VIBCH
GUAA_VIBCM
GUAA_VIBPA
GUAA_VIBVU
GUAA_VIBVY
GUAA_WIGBR
GUAA_WOLPM
GUAA_WOLPP
GUAA_WOLSU
GUAA_WOLTR
GUAA_WOLWR
GUAA_XANAC
GUAA_XANC5
GUAA_XANC8
GUAA_XANCB
GUAA_XANCP
GUAA_XANOM
GUAA_XANOP
GUAA_XANOR
GUAA_XYLF2
GUAA_XYLFA
GUAA_XYLFM
GUAA_XYLFT
GUAA_YARLI
GUAA_YEAST
GUAA_YERE8
GUAA_YERP3
GUAA_YERPA
GUAA_YERPB
GUAA_YERPE
GUAA_YERPG
GUAA_YERPN
GUAA_YERPP
GUAA_YERPS
GUAA_YERPY
GUAA_ZYMMO
References
-
Lagerkvist, U.Biosynthesis of guanosine 5'-phosphate. II. Amination of xanthosine 5'-phosphate by purified enzyme from pigeon liver.J. Biol. Chem. 233 : 143-149 (1958). [PMID: 13563458]
-
Abrams, R. and Bentley, M.Biosynthesis of nucleic acid purines. III. Guanosine 5'-phosphate formation from xanthosine 5'-phosphate and L-glutamine.Arch. Biochem. Biophys. 79 : 91-110 (1959).
-
Zalkin, H., Argos, P., Narayana, S. V., Tiedeman, A. A., Smith, J. M.Identification of a trpG-related glutamine amide transfer domain in Escherichia coli GMP synthetase.J. Biol. Chem. 260 : 3350-3354 (1985). [PMID: 2982857]
-
Abbott, J. L., Newell, J. M., Lightcap, C. M., Olanich, M. E., Loughlin, D. T., Weller, M. A., Lam, G., Pollack, S., Patton, W. A.The effects of removing the GAT domain from E. coli GMP synthetase.Protein J. 25 : 483-491 (2006). [PMID: 17103135]
[EC 6.3.5.2 created 1961, modified 2013]