EC 6 - Ligases
EC 6.3 - Forming carbon-nitrogen bonds
EC 6.3.5 - Carbon—nitrogen ligases with glutamine as amido-N-donor
EC 6.3.5.1 - NAD+ synthase (glutamine-hydrolysing)
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 6.3.5.1
Names
Accepted name:
NAD+ synthase (glutamine-hydrolysing)
Other
names:
DPN synthetase
NAD synthetase (glutamine-hydrolysing)
desamidonicotinamide adenine dinucleotide amidotransferase
nicotinamide adenine dinucleotide synthetase (glutamine)
NAD+ synthetase (glutamine-hydrolyzing)
NAD synthetase (glutamine-hydrolysing)
desamidonicotinamide adenine dinucleotide amidotransferase
nicotinamide adenine dinucleotide synthetase (glutamine)
NAD+ synthetase (glutamine-hydrolyzing)
Systematic name:
deamido-NAD+:L-glutamine amido-ligase (AMP-forming)
Reaction
- ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate
Comments:
NH3 can act instead of glutamine (cf. EC 6.3.1.5 NAD+ synthase).
Links to other databases
Protein domains and families:
PROSITE:PDOC50263
Gene Ontology:
GO:0003952
CAS Registry Number:
37318-70-0
References
-
Pathway of diphosphopyridine nucleotide biosynthesis in Escherichia coli.J. Biol. Chem. 236 : 1494-1497 (1961).
-
Biosynthesis of diphosphopyridine nucleotide. III. Nicotinic acid mononucleotide pyrophosphorylase.J. Biol. Chem. 236 : 525-530 (1961).
[EC 6.3.5.1 created 1961]