EC - Argininosuccinate synthase

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IntEnz Enzyme Nomenclature


Accepted name:
argininosuccinate synthase
Other names:
arginine succinate synthetase
argininosuccinate synthetase
argininosuccinic acid synthetase
arginosuccinate synthetase
citrulline—aspartate ligase
Systematic name:
L-citrulline:L-aspartate ligase (AMP-forming)


Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00488
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004055
CAS Registry Number: 9023-58-9
UniProtKB/Swiss-Prot: (607) [show] [UniProt]


  1. Ratner, S.
    Urea synthesis and metabolism of arginine and citrulline.
    Adv. Enzymol. Relat. Subj. Biochem. 15 : 319-387 (1954).
  2. Schuegraf, A., Ratner, S. and Warner, R.C.
    Free energy changes of the argininosuccinate synthetase reaction and of the hydrolysis of the inner pyrophosphate bond of adenosine triphosphate.
    J. Biol. Chem. 235 : 3597-3602 (1960). [PMID: 13748745]

[EC created 1961]