EC - Formate—tetrahydrofolate ligase

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IntEnz Enzyme Nomenclature


Accepted name:
formate—tetrahydrofolate ligase
Other names:
10-formyltetrahydrofolate synthetase
formyltetrahydrofolate synthetase
tetrahydrofolate formylase
tetrahydrofolic formylase
Systematic name:
formate:tetrahydrofolate ligase (ADP-forming)



In eukaryotes occurs as a trifunctional enzyme also having methylenetetrahydrofolate dehydrogenase (EC and methenyltetrahydrofolate cyclohydrolase (EC activity.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00595
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004329
CAS Registry Number: 9023-66-9
UniProtKB/Swiss-Prot: (313) [show] [UniProt]


  1. Jaenicke, L. and Brode, E.
    Untersuchungen über Einkohlenstoffkörper. I. Die Tetrahydrofolatformylase aus Taubenleber. Rinigung und Mechanismus.
    Biochem. Z. 334: 108-132 (1961). [PMID: 13789141]
  2. Long, C.W., Levitzki, A., Houston, L.L and Koshland, D.E., Jr.
    Subunit structures and interactions of CTP synthetase.
    Fed. Proc. 28: 342 (1969).
  3. Rabinowitz, J.C. and Pricer, W.E., Jr.
    Formyltetrahydrofolate synthetase. I. Isolation and crystallization of the enzyme.
    J. Biol. Chem. 237: 2898-2902 (1962). [PMID: 14489619]
  4. Whiteley, H.R., Osborn, M.J. and Huennekens, F.M.
    Purification and properties of the formate-activating enzyme from Micrococcus aerogenes.
    J. Biol. Chem. 234: 1538-1543 (1959). [PMID: 13654413]

[EC created 1961]