EC - 7-cyano-7-deazaguanine synthase

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IntEnz Enzyme Nomenclature


Accepted name:
7-cyano-7-deazaguanine synthase
Other names:
preQ0 synthase
7-cyano-7-carbaguanine synthase
queC (gene name)
Systematic name:
7-carboxy-7-carbaguanine:ammonia ligase (ADP-forming)



Binds Zn2+. The reaction is part of the biosynthesis pathway of queuosine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (520) [show] [UniProt]


  1. McCarty, R. M., Somogyi, A., Lin, G., Jacobsen, N. E., Bandarian, V.
    The deazapurine biosynthetic pathway revealed: in vitro enzymatic synthesis of PreQ(0) from guanosine 5'-triphosphate in four steps.
    Biochemistry 48 : 3847-3852 (2009). [PMID: 19354300]
  2. Cicmil, N., Huang, R. H.
    Crystal structure of QueC from Bacillus subtilis: an enzyme involved in preQ1 biosynthesis.
    Proteins 72 : 1084-1088 (2008). [PMID: 18491386]

[EC created 2012]