EC 6.3.4.2 - CTP synthase (glutamine hydrolyzing)
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 6.3.4.2
Names
Accepted name:
CTP synthase (glutamine hydrolyzing)
Other
names:
UTP—ammonia ligase
cytidine 5'-triphosphate synthetase
cytidine triphosphate synthetase
uridine triphosphate aminase
CTP synthetase
CTPS (gene name)
pyrG (gene name)
cytidine 5'-triphosphate synthetase
cytidine triphosphate synthetase
uridine triphosphate aminase
CTP synthetase
CTPS (gene name)
pyrG (gene name)
Systematic name:
UTP:L-glutamine amido-ligase (ADP-forming)
Reactions
- (1) ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate
- (1a) L-glutamine + H2O = L-glutamate + NH3
- (1b) ATP + UTP + NH3 = ADP + phosphate + CTP
Comments:
The enzyme contains three functionally distinct sites: an allosteric GTP-binding site, a glutaminase site where glutamine hydrolysis occurs (cf. EC 3.5.1.2, glutaminase), and the active site where CTP synthesis takes place. The reaction proceeds via phosphorylation of UTP by ATP to give an activated intermediate 4-phosphoryl UTP and ADP [4,5]. Ammonia then reacts with this intermediate generating CTP and a phosphate. The enzyme can also use ammonia from the surrounding solution [3,6].
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
ERGO
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Protein domains and families:
PROSITE:PDOC00405
Gene Ontology:
GO:0003883
CAS Registry Number:
9023-56-7
PYG1A-2_XENLA
PYG1A_XENLA
PYG1B_XENLA
PYRG-2_DROME
PYRG1-2_HUMAN
PYRG1_CRIGR
PYRG1_DANRE
PYRG1_HUMAN
PYRG1_MOUSE
PYRG2-2_MOUSE
PYRG2-3_MOUSE
PYRG2_BOVIN
PYRG2_CHICK
PYRG2_HUMAN
PYRG2_MOUSE
PYRG2_RAT
PYRG2_XENLA
PYRG_ACAM1
PYRG_ACET2
PYRG_ACIAC
PYRG_ACIAD
PYRG_ACIB3
PYRG_ACIB5
PYRG_ACIBC
PYRG_ACIBS
PYRG_ACIBT
PYRG_ACIBY
PYRG_ACIC1
PYRG_ACIC5
PYRG_ACICJ
PYRG_ACIET
PYRG_ACIF2
PYRG_ACIF5
PYRG_ACISJ
PYRG_ACTP2
PYRG_ACTP7
PYRG_ACTPJ
PYRG_ACTSZ
PYRG_AERHH
PYRG_AERPE
PYRG_AERS4
PYRG_AGRFC
PYRG_ALCBS
PYRG_ALIF1
PYRG_ALIFM
PYRG_ALISL
PYRG_ALKEH
PYRG_ALKHC
PYRG_ALTMD
PYRG_ANAD2
PYRG_ANADE
PYRG_ANADF
PYRG_ANAMF
PYRG_ANAMM
PYRG_ANAPZ
PYRG_ANASK
PYRG_AQUAE
PYRG_ARCFU
PYRG_AROAE
PYRG_ASHGO
PYRG_AYWBP
PYRG_AZOBR
PYRG_AZOSB
PYRG_AZOVD
PYRG_BACAA
PYRG_BACAC
PYRG_BACAH
PYRG_BACAN
PYRG_BACC0
PYRG_BACC1
PYRG_BACC2
PYRG_BACC3
PYRG_BACC4
PYRG_BACC7
PYRG_BACCN
PYRG_BACCQ
PYRG_BACCR
PYRG_BACCZ
PYRG_BACFN
PYRG_BACFR
PYRG_BACHK
PYRG_BACLD
PYRG_BACMK
PYRG_BACP2
PYRG_BACSK
PYRG_BACSU
PYRG_BACTN
PYRG_BACVZ
PYRG_BARBK
PYRG_BARHE
PYRG_BARQU
PYRG_BART1
PYRG_BAUCH
PYRG_BDEBA
PYRG_BEII9
PYRG_BIFLO
PYRG_BLOFL
PYRG_BLOPB
PYRG_BORA1
PYRG_BORAP
PYRG_BORBP
PYRG_BORBR
PYRG_BORBU
PYRG_BORPA
PYRG_BORPD
PYRG_BORPE
PYRG_BRADU
PYRG_BRASB
PYRG_BRASO
PYRG_BRUA1
PYRG_BRUA2
PYRG_BRUA4
PYRG_BRUAB
PYRG_BRUC2
PYRG_BRUMB
PYRG_BRUME
PYRG_BRUO2
PYRG_BRUSI
PYRG_BRUSU
PYRG_BUCA5
PYRG_BUCAI
PYRG_BUCAP
PYRG_BUCAT
PYRG_BUCBP
PYRG_BURA4
PYRG_BURCA
PYRG_BURCC
PYRG_BURCH
PYRG_BURCJ
PYRG_BURCM
PYRG_BURL3
PYRG_BURM1
PYRG_BURM7
PYRG_BURM9
PYRG_BURMA
PYRG_BURMS
PYRG_BURP1
PYRG_BURPS
PYRG_BURTA
PYRG_BURVG
PYRG_CALMQ
PYRG_CALS4
PYRG_CAMJ8
PYRG_CAMJD
PYRG_CAMJE
PYRG_CAMJJ
PYRG_CAMJR
PYRG_CANGA
PYRG_CARHZ
PYRG_CAUSK
PYRG_CAUVC
PYRG_CAUVN
PYRG_CERS4
PYRG_CERS5
PYRG_CHESB
PYRG_CHLAA
PYRG_CHLAB
PYRG_CHLAD
PYRG_CHLCH
PYRG_CHLCV
PYRG_CHLFF
PYRG_CHLL2
PYRG_CHLL3
PYRG_CHLMU
PYRG_CHLP8
PYRG_CHLPB
PYRG_CHLPD
PYRG_CHLPM
PYRG_CHLPN
PYRG_CHLSY
PYRG_CHLT2
PYRG_CHLT3
PYRG_CHLTA
PYRG_CHLTB
PYRG_CHLTE
PYRG_CHLTR
PYRG_CHRSD
PYRG_CHRVO
PYRG_CITK8
PYRG_CLOAB
PYRG_CLOB8
PYRG_CLOK5
PYRG_CLOP1
PYRG_CLOPE
PYRG_CLOPS
PYRG_COLP3
PYRG_COPPD
PYRG_COREF
PYRG_CORGB
PYRG_CORGL
PYRG_CORJK
PYRG_CORK4
PYRG_COXB1
PYRG_COXB2
PYRG_COXBN
PYRG_COXBR
PYRG_COXBU
PYRG_CROS5
PYRG_CROS8
PYRG_CUPMC
PYRG_CUPNH
PYRG_CUPPJ
PYRG_CUPTR
PYRG_CUTAK
PYRG_CYAP4
PYRG_CYTH3
PYRG_DECAR
PYRG_DEHM1
PYRG_DEHMB
PYRG_DEHMC
PYRG_DEIDV
PYRG_DEIGD
PYRG_DEIRA
PYRG_DELAS
PYRG_DESAG
PYRG_DESDA
PYRG_DESHY
PYRG_DESPS
PYRG_DESVH
PYRG_DESVM
PYRG_DESVV
PYRG_DICDI
PYRG_DICNV
PYRG_DINSH
PYRG_DROME
PYRG_DROPS
PYRG_ECO24
PYRG_ECO27
PYRG_ECO45
PYRG_ECO55
PYRG_ECO57
PYRG_ECO5E
PYRG_ECO7I
PYRG_ECO81
PYRG_ECO8A
PYRG_ECOBW
PYRG_ECODH
PYRG_ECOHS
PYRG_ECOK1
PYRG_ECOL5
PYRG_ECOL6
PYRG_ECOLC
PYRG_ECOLI
PYRG_ECOLU
PYRG_ECOSE
PYRG_ECOSM
PYRG_ECOUT
PYRG_EDWI9
PYRG_EHRCJ
PYRG_EHRCR
PYRG_EHRRG
PYRG_EHRRW
PYRG_ENCCU
PYRG_ENT38
PYRG_ENTFA
PYRG_ERWT9
PYRG_ERYLH
PYRG_ESCF3
PYRG_FIBSS
PYRG_FLAJ1
PYRG_FLAPJ
PYRG_FRACC
PYRG_FRAP2
PYRG_FRAT1
PYRG_FRATF
PYRG_FRATH
PYRG_FRATM
PYRG_FRATN
PYRG_FRATO
PYRG_FRATT
PYRG_FRATW
PYRG_GEODF
PYRG_GEOKA
PYRG_GEOLS
PYRG_GEOMG
PYRG_GEOSL
PYRG_GEOUR
PYRG_GIBZE
PYRG_GLOC7
PYRG_GLOVI
PYRG_GLUDA
PYRG_GLUOX
PYRG_GRABC
PYRG_GRAFK
PYRG_HAEDU
PYRG_HAEI8
PYRG_HAEIE
PYRG_HAEIG
PYRG_HAEIN
PYRG_HAEPS
PYRG_HAES1
PYRG_HAHCH
PYRG_HALHL
PYRG_HALHT
PYRG_HALMA
PYRG_HALS3
PYRG_HALSA
PYRG_HALWD
PYRG_HAMD5
PYRG_HELHP
PYRG_HELPH
PYRG_HELPJ
PYRG_HELPY
PYRG_HERA2
PYRG_HERAR
PYRG_HYDCU
PYRG_HYDS0
PYRG_HYPNA
PYRG_IDILO
PYRG_JANMA
PYRG_JANSC
PYRG_KLEP3
PYRG_KLEP7
PYRG_KORVE
PYRG_LACAC
PYRG_LACDA
PYRG_LACDB
PYRG_LACH4
PYRG_LACJO
PYRG_LACLA
PYRG_LACLM
PYRG_LACPL
PYRG_LARHH
PYRG_LATSS
PYRG_LAWIP
PYRG_LEGPA
PYRG_LEGPC
PYRG_LEGPH
PYRG_LEGPL
PYRG_LEIXX
PYRG_LEPCP
PYRG_LEPIC
PYRG_LEPIN
PYRG_LEVBA
PYRG_LIGS1
PYRG_LISIN
PYRG_LISMF
PYRG_LISMO
PYRG_MAGSA
PYRG_MANSM
PYRG_MARMM
PYRG_MARN8
PYRG_MARSD
PYRG_MESFL
PYRG_META3
PYRG_METAC
PYRG_METB6
PYRG_METBF
PYRG_METBU
PYRG_METC4
PYRG_METCA
PYRG_METFK
PYRG_METHJ
PYRG_METJA
PYRG_METKA
PYRG_METLZ
PYRG_METMA
PYRG_METMJ
PYRG_METMP
PYRG_METNO
PYRG_METPB
PYRG_METPE
PYRG_METRJ
PYRG_METS4
PYRG_METSB
PYRG_METST
PYRG_METTH
PYRG_METTP
PYRG_MICAN
PYRG_MOOTA
PYRG_MYCA1
PYRG_MYCBO
PYRG_MYCBP
PYRG_MYCBT
PYRG_MYCCC
PYRG_MYCCT
PYRG_MYCGI
PYRG_MYCLB
PYRG_MYCLE
PYRG_MYCMM
PYRG_MYCMS
PYRG_MYCPA
PYRG_MYCPU
PYRG_MYCS2
PYRG_MYCSJ
PYRG_MYCSK
PYRG_MYCSS
PYRG_MYCTA
PYRG_MYCTO
PYRG_MYCTU
PYRG_MYCUA
PYRG_MYCVP
PYRG_MYXXD
PYRG_NATPD
PYRG_NATTJ
PYRG_NAUPA
PYRG_NEIG1
PYRG_NEIG2
PYRG_NEIM0
PYRG_NEIMA
PYRG_NEIMB
PYRG_NEIMF
PYRG_NEOSM
PYRG_NEUCR
PYRG_NITEC
PYRG_NITEU
PYRG_NITHX
PYRG_NITMU
PYRG_NITOC
PYRG_NITWN
PYRG_NOCFA
PYRG_NOCSJ
PYRG_NOSP7
PYRG_NOSS1
PYRG_NOVAD
PYRG_OCEIH
PYRG_ONYPE
PYRG_PARDP
PYRG_PARL1
PYRG_PARMW
PYRG_PARP8
PYRG_PARPJ
PYRG_PARUW
PYRG_PARXL
PYRG_PASMU
PYRG_PECAS
PYRG_PECCP
PYRG_PELPB
PYRG_PELPD
PYRG_PELTS
PYRG_PELUB
PYRG_PHEZH
PYRG_PHOLL
PYRG_PHOPR
PYRG_PHYAS
PYRG_PICTO
PYRG_POLAQ
PYRG_POLNA
PYRG_POLNS
PYRG_POLSJ
PYRG_PORG3
PYRG_PORGI
PYRG_PROA2
PYRG_PROM0
PYRG_PROM1
PYRG_PROM2
PYRG_PROM3
PYRG_PROM4
PYRG_PROM5
PYRG_PROM9
PYRG_PROMA
PYRG_PROMH
PYRG_PROMM
PYRG_PROMP
PYRG_PROMS
PYRG_PROMT
PYRG_PSE14
PYRG_PSEA6
PYRG_PSEA7
PYRG_PSEA8
PYRG_PSEAB
PYRG_PSEAE
PYRG_PSEE4
PYRG_PSEF5
PYRG_PSEFS
PYRG_PSEMY
PYRG_PSEP1
PYRG_PSEPF
PYRG_PSEPG
PYRG_PSEPK
PYRG_PSEPW
PYRG_PSESM
PYRG_PSET1
PYRG_PSEU2
PYRG_PSEU5
PYRG_PSYA2
PYRG_PSYCK
PYRG_PSYIN
PYRG_PSYWF
PYRG_PYRAB
PYRG_PYRAE
PYRG_PYRCJ
PYRG_PYRFU
PYRG_PYRHO
PYRG_RALPJ
PYRG_RALSO
PYRG_RHIE6
PYRG_RHIEC
PYRG_RHIL3
PYRG_RHILO
PYRG_RHILW
PYRG_RHIME
PYRG_RHOBA
PYRG_RHOCS
PYRG_RHOFT
PYRG_RHOJR
PYRG_RHOOB
PYRG_RHOP2
PYRG_RHOP5
PYRG_RHOPA
PYRG_RHOPB
PYRG_RHOPS
PYRG_RHOPT
PYRG_RHORT
PYRG_RHOS1
PYRG_RHOSK
PYRG_RICBR
PYRG_RICCN
PYRG_RICFE
PYRG_RICPR
PYRG_RICPU
PYRG_RICRO
PYRG_RICRS
PYRG_RICTY
PYRG_RIPO1
PYRG_ROSCS
PYRG_ROSDO
PYRG_ROSS1
PYRG_RUBXD
PYRG_RUEPO
PYRG_RUEST
PYRG_RUMCH
PYRG_SACD2
PYRG_SACEN
PYRG_SACS2
PYRG_SALA4
PYRG_SALAR
PYRG_SALCH
PYRG_SALDC
PYRG_SALEP
PYRG_SALG2
PYRG_SALHS
PYRG_SALNS
PYRG_SALPA
PYRG_SALPB
PYRG_SALPC
PYRG_SALPK
PYRG_SALRD
PYRG_SALSV
PYRG_SALTI
PYRG_SALTY
PYRG_SCHPO
PYRG_SERP5
PYRG_SHEAM
PYRG_SHEB2
PYRG_SHEB5
PYRG_SHEB8
PYRG_SHEB9
PYRG_SHEDO
PYRG_SHEFN
PYRG_SHEHH
PYRG_SHELP
PYRG_SHEON
PYRG_SHEPA
PYRG_SHEPC
PYRG_SHESA
PYRG_SHESH
PYRG_SHESM
PYRG_SHESR
PYRG_SHESW
PYRG_SHEWM
PYRG_SHIB3
PYRG_SHIBS
PYRG_SHIDS
PYRG_SHIF8
PYRG_SHIFL
PYRG_SHISS
PYRG_SINMW
PYRG_SODGM
PYRG_SPHAL
PYRG_SPHWW
PYRG_SPICI
PYRG_STAA1
PYRG_STAA2
PYRG_STAA3
PYRG_STAA8
PYRG_STAA9
PYRG_STAAB
PYRG_STAAC
PYRG_STAAE
PYRG_STAAM
PYRG_STAAN
PYRG_STAAR
PYRG_STAAS
PYRG_STAAT
PYRG_STAAW
PYRG_STACT
PYRG_STAEQ
PYRG_STAES
PYRG_STAHJ
PYRG_STAS1
PYRG_STRA1
PYRG_STRA3
PYRG_STRA5
PYRG_STRAW
PYRG_STRCO
PYRG_STRE4
PYRG_STRGC
PYRG_STRGG
PYRG_STRM5
PYRG_STRMK
PYRG_STRMU
PYRG_STRP1
PYRG_STRP3
PYRG_STRP6
PYRG_STRP8
PYRG_STRPB
PYRG_STRPC
PYRG_STRPD
PYRG_STRPF
PYRG_STRPM
PYRG_STRPN
PYRG_STRPQ
PYRG_STRR6
PYRG_STRS7
PYRG_STRSV
PYRG_STRT1
PYRG_STRT2
PYRG_SULAC
PYRG_SULDN
PYRG_SULTO
PYRG_SYMTH
PYRG_SYNAS
PYRG_SYNC1
PYRG_SYNE7
PYRG_SYNJA
PYRG_SYNJB
PYRG_SYNP2
PYRG_SYNP6
PYRG_SYNPW
PYRG_SYNR3
PYRG_SYNS3
PYRG_SYNS9
PYRG_SYNSC
PYRG_SYNWW
PYRG_SYNY3
PYRG_THEAB
PYRG_THEAC
PYRG_THEFY
PYRG_THEGJ
PYRG_THEKO
PYRG_THEMA
PYRG_THEON
PYRG_THERP
PYRG_THET2
PYRG_THET8
PYRG_THEVB
PYRG_THEVO
PYRG_THIDA
PYRG_THISH
PYRG_TOLAT
PYRG_TREDE
PYRG_TREPA
PYRG_TREPS
PYRG_TRIEI
PYRG_TRIV2
PYRG_TROW8
PYRG_TROWT
PYRG_UREPA
PYRG_VARPS
PYRG_VEREI
PYRG_VIBA3
PYRG_VIBC3
PYRG_VIBCB
PYRG_VIBCH
PYRG_VIBCM
PYRG_VIBPA
PYRG_VIBVU
PYRG_VIBVY
PYRG_WIGBR
PYRG_WOLPM
PYRG_WOLSU
PYRG_WOLTR
PYRG_XANAC
PYRG_XANC5
PYRG_XANC8
PYRG_XANCB
PYRG_XANCP
PYRG_XANOM
PYRG_XANOP
PYRG_XANOR
PYRG_XYLF2
PYRG_XYLFA
PYRG_XYLFM
PYRG_XYLFT
PYRG_YERE8
PYRG_YERP3
PYRG_YERPA
PYRG_YERPB
PYRG_YERPE
PYRG_YERPG
PYRG_YERPN
PYRG_YERPP
PYRG_YERPS
PYRG_YERPY
PYRG_ZYMMO
URA7_YEAST
URA8_YEAS7
URA8_YEAST
References
-
Lieberman, I.Enzymatic amination of uridine triphosphate to cytidine triphosphate.J. Biol. Chem. 222 : 765-775 (1956). [PMID: 13367044]
-
Long, C.W., Levitzki, A., Houston, L.L and Koshland, D.E., JrSubunit structures and interactions of CTP synthetase.Fed. Proc. 28 : 342 (1969).
-
Levitzki, A., Koshland, D. E.Ligand-induced dimer-to-tetramer transformation in cytosine triphosphate synthetase.Biochemistry 11 : 247-253 (1972). [PMID: 4550560]
-
von der Saal, W., Anderson, P. M., Villafranca, J. J.Mechanistic investigations of Escherichia coli cytidine-5'-triphosphate synthetase. Detection of an intermediate by positional isotope exchange experiments.J. Biol. Chem. 260 : 14993-14997 (1985). [PMID: 2933396]
-
Lewis, D. A., Villafranca, J. J.Investigation of the mechanism of CTP synthetase using rapid quench and isotope partitioning methods.Biochemistry 28 : 8454-8459 (1989). [PMID: 2532543]
-
Wadskov-Hansen, S. L., Willemoes, M., Martinussen, J., Hammer, K., Neuhard, J., Larsen, S.Cloning and verification of the Lactococcus lactis pyrG gene and characterization of the gene product, CTP synthase.J. Biol. Chem. 276 : 38002-38009 (2001). [PMID: 11500486]
[EC 6.3.4.2 created 1961, modified 2013]