EC - Phosphoribosylaminoimidazolesuccinocarboxamide synthase

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IntEnz Enzyme Nomenclature


Accepted name:
phosphoribosylaminoimidazolesuccinocarboxamide synthase
Other names:
phosphoribosylaminoimidazole-succinocarboxamide synthetase
SAICAR synthase
phosphoribosylaminoimidazole-succinocarboxamide synthase
SAICAR synthetase
4-(N-succinocarboxamide)-5-aminoimidazole synthetase
4-[(N-succinylamino)carbonyl]-5-aminoimidazole ribonucleotide synthetase
5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase
phosphoribosylaminoimidazolesuccinocarboxamide synthetase
Systematic name:
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming)



Forms part of the purine biosynthesis pathway.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00810
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004639
CAS Registry Number: 9023-67-0
UniProtKB/Swiss-Prot: (542) [show] [UniProt]


  1. Lukens, L.N. and Buchanan, J.M.
    Biosynthesis of purines. XXIV. The enzymatic synthesis of 5-amino-1-ribosyl-4-imidazolecarboxylic acid 5'-phosphate from 5-amino-1-ribosylimidazole 5'-phosphate and carbon dioxide.
    J. Biol. Chem. 234 : 1799-1805 (1959). [PMID: 13672967]
  2. Parker, J.
    Identification of the purC gene product of Escherichia coli.
    J. Bacteriol. 157 : 712-717 (1984). [PMID: 6365889]
  3. Ebbole, D.J. and Zalkin, H.
    Cloning and characterization of a 12-gene cluster from Bacillus subtilis encoding nine enzymes for de novo purine nucleotide synthesis.
    J. Biol. Chem. 262 : 8274-8287 (1987). [PMID: 3036807]
  4. Chen, Z.D., Dixon, J.E. and Zalkin, H.
    Cloning of a chicken liver cDNA encoding 5-aminoimidazole ribonucleotide carboxylase and 5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase by functional complementation of Escherichia coli pur mutants.
    Proc. Natl. Acad. Sci. USA 87 : 3097-3101 (1990). [PMID: 1691501]
  5. O'Donnell, A.F., Tiong, S., Nash, D. and Clark, D.V.
    The Drosophila melanogaster ade5 gene encodes a bifunctional enzyme for two steps in the de novo purine synthesis pathway.
    Genetics 154 : 1239-1253 (2000). [PMID: 10757766]
  6. Nelson, S.W., Binkowski, D.J., Honzatko, R.B. and Fromm, H.J.
    Mechanism of action of Escherichia coli phosphoribosylaminoimidazolesuccinocarboxamide synthetase.
    Biochemistry 44 : 766-774 (2005). [PMID: 15641804]

[EC created 1961, modified 2000, modified 2006]