EC - Phosphopantothenate—cysteine ligase (CTP)

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
phosphopantothenate—cysteine ligase (CTP)
Other names:
phosphopantothenoylcysteine synthetase [ambiguous]
phosphopantothenate—cysteine ligase [ambiguous]
Systematic name:
(R)-4'-phosphopantothenate:L-cysteine ligase



A key enzyme in the production of coenzyme A. The bacterial enzyme requires CTP, in contrast to the eukaryotic enzyme, EC, which requires ATP. Cysteine can be replaced by some of its derivatives.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004632
CAS Registry Number: 9023-50-1
UniProtKB/Swiss-Prot: (21) [show] [UniProt]


  1. Brown, G.M.
    The metabolism of pantothenic acid.
    J. Biol. Chem. 234 : 370-378 (1959). [PMID: 13630913]
  2. Strauss, E., Kinsland, C., Ge, Y., McLafferty, F.W. and Begley, T.P.
    Phosphopantothenoylcysteine synthetase from Escherichia coli. Identification and characterization of the last unidentified Coenzyme A biosynthetic enzymes in bacteria.
    J. Biol. Chem. 276 : 13513-13516 (2001). [PMID: 11278255]
  3. Kupke, T.
    Molecular characterization of the 4'-phosphopantothenoylcysteine synthetase domain of bacterial Dfp flavoproteins.
    J. Biol. Chem. 277 : 36137-36145 (2002). [PMID: 12140293]
  4. Stanitzek, S., Augustin, M. A., Huber, R., Kupke, T., Steinbacher, S.
    Structural basis of CTP-dependent peptide bond formation in coenzyme A biosynthesis catalyzed by Escherichia coli PPC synthetase.
    Structure 12 : 1977-1988 (2004). [PMID: 15530362]

[EC created 1961, modified 2003, modified 2017]