EC 6.3.2.40 - Cyclopeptine synthase

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IntEnz Enzyme Nomenclature
EC 6.3.2.40

Names

Accepted name:
cyclopeptine synthase
Systematic name:
S-adenosyl-L-methionine:anthranilate:L-phenylalanine ligase (cyclopeptine forming)

Reaction

Comments:

Cyclopeptine synthase is the key enzyme of benzodiazepine alkaloid biosynthesis in the fungus Penicillium cyclopium. The enzyme is a non-ribosomal peptide synthase. Formerly EC 2.7.7.54 and EC 2.7.7.55.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Lerbs, W., Luckner, M.
    Cyclopeptine synthetase activity in surface cultures of Penicillium cyclopium.
    J. Basic Microbiol. 25: 387-391 (1985). [PMID: 2995633]
  2. Gerlach, M, Schwelle, N., Lerbs, W. and Luckner, M.
    Enzymatic synthesis of cyclopeptine intermediates in Penicillium cyclopium.
    Phytochemistry 24: 1935-1939 (1985).

[EC 6.3.2.40 created 2013]