EC 6.3.2.4 - D-alanine—D-alanine ligase

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IntEnz Enzyme Nomenclature
EC 6.3.2.4

Names

Accepted name:
D-alanine—D-alanine ligase
Other names:
MurE synthetase [ambiguous]
alanine:alanine ligase (ADP-forming)
alanylalanine synthetase
D-Ala-D-Ala synthetase
D-alanylalanine synthetase
D-alanyl-D-alanine synthetase
Systematic name:
D-alanine:D-alanine ligase (ADP-forming)

Reaction

Comments:

Involved with EC 6.3.2.7 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—L-lysine ligase) or EC 6.3.2.13 (UDP-N-acetylmuramoylalanyl-D-glutamate—2,6-diaminopimelate ligase), EC 6.3.2.8 (UDP-N-acetylmuramate—L-alanine ligase), EC 6.3.2.9 (UDP-N acetylmuramoylalanine—D-glutamate ligase) and EC 6.3.2.10 (UDP-N-acetylmuramoyl-tripeptide—D-alanyl-D-alanine ligase) in the synthesis of a cell-wall peptide.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00659 , PROSITE:PDOC50975
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008716
CAS Registry Number: 9023-63-6
UniProtKB/Swiss-Prot: (587) [show] [UniProt]

References

  1. Ito, E. and Strominger, J.L.
    Enzymatic synthesis of the peptide in bacterial uridine nucleotides. II. Enzymatic synthesis and addition of D-alanyl-D-alanine.
    J. Biol. Chem. 237 : 2696-2703 (1962).
  2. Neuhaus, F.C.
    Kinetic studies on D-Ala-D-Ala synthetase.
    Fed. Proc. 21 : 229 (1962).
  3. van Heijenoort, J.
    Recent advances in the formation of the bacterial peptidoglycan monomer unit.
    Nat. Prod. Rep. 18 : 503-519 (2001). [PMID: 11699883]

[EC 6.3.2.4 created 1961, modified 2002]