EC 6 - Ligases
EC 6.3 - Forming carbon-nitrogen bonds
EC 6.3.2 - Acid—amino-acid ligases (peptide synthases)
EC 6.3.2.4 - D-alanine—D-alanine ligase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 6.3.2.4
Names
Accepted name:
D-alanine—D-alanine ligase
Other
names:
MurE synthetase
[ambiguous]
alanine:alanine ligase (ADP-forming)
alanylalanine synthetase
D-Ala-D-Ala synthetase
D-alanylalanine synthetase
D-alanyl-D-alanine synthetase
alanine:alanine ligase (ADP-forming)
alanylalanine synthetase
D-Ala-D-Ala synthetase
D-alanylalanine synthetase
D-alanyl-D-alanine synthetase
Systematic name:
D-alanine:D-alanine ligase (ADP-forming)
Reaction
- ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine
Comments:
Involved with EC 6.3.2.7 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—L-lysine ligase) or EC 6.3.2.13 (UDP-N-acetylmuramoylalanyl-D-glutamate—2,6-diaminopimelate ligase), EC 6.3.2.8 (UDP-N-acetylmuramate—L-alanine ligase), EC 6.3.2.9 (UDP-N acetylmuramoylalanine—D-glutamate ligase) and EC 6.3.2.10 (UDP-N-acetylmuramoyl-tripeptide—D-alanyl-D-alanine ligase) in the synthesis of a cell-wall peptide.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Protein domains and families:
PROSITE:PDOC00659
,
PROSITE:PDOC50975
Gene Ontology:
GO:0008716
CAS Registry Number:
9023-63-6
DDLA_BACCR
DDLA_BRADU
DDLA_BRUME
DDLA_BRUSU
DDLA_CHRVO
DDLA_CLOPE
DDLA_CLOTE
DDLA_ECO57
DDLA_ECOL6
DDLA_ECOLI
DDLA_PSEAE
DDLA_PSEPK
DDLA_PSESM
DDLA_RHILO
DDLA_SALTI
DDLA_SALTY
DDLA_SHIFL
DDLA_XANCP
DDLB_BACCR
DDLB_BRADU
DDLB_BRUME
DDLB_BRUSU
DDLB_CHRVO
DDLB_CLOPE
DDLB_CLOTE
DDLB_ECO57
DDLB_ECOL6
DDLB_ECOLI
DDLB_PSEAE
DDLB_PSEPK
DDLB_PSESM
DDLB_RHILO
DDLB_SALTI
DDLB_SALTY
DDLB_SHIFL
DDLB_XANCP
DDL_ACAM1
DDL_ACET2
DDL_ACIAC
DDL_ACIAD
DDL_ACIB3
DDL_ACIB5
DDL_ACIBC
DDL_ACIBS
DDL_ACIBT
DDL_ACIBY
DDL_ACICJ
DDL_ACIET
DDL_ACISJ
DDL_ACTP2
DDL_ACTP7
DDL_ACTPJ
DDL_ACTSZ
DDL_AERHH
DDL_AERS4
DDL_AFIC5
DDL_AGRFC
DDL_ALCBS
DDL_ALIF1
DDL_ALIFM
DDL_ALKEH
DDL_ALKHC
DDL_ANACE
DDL_ANAD2
DDL_ANADE
DDL_ANADF
DDL_ANAMF
DDL_ANAMM
DDL_ANASK
DDL_AQUAE
DDL_AROAE
DDL_ARTS2
DDL_AZOC5
DDL_AZOPC
DDL_AZOSB
DDL_BACAA
DDL_BACAC
DDL_BACAN
DDL_BACCN
DDL_BACFN
DDL_BACFR
DDL_BACLD
DDL_BACP2
DDL_BACSK
DDL_BACSU
DDL_BACTN
DDL_BACVZ
DDL_BARBK
DDL_BARHE
DDL_BARQU
DDL_BART1
DDL_BAUCH
DDL_BDEBA
DDL_BEII9
DDL_BIFA0
DDL_BIFAA
DDL_BIFLD
DDL_BIFLO
DDL_BIFLS
DDL_BLOFL
DDL_BLOPB
DDL_BORA1
DDL_BORAP
DDL_BORBP
DDL_BORBR
DDL_BORBU
DDL_BORBZ
DDL_BORDL
DDL_BORHD
DDL_BORPA
DDL_BORPD
DDL_BORPE
DDL_BORRA
DDL_BORT9
DDL_BRASB
DDL_BRASO
DDL_BRUA4
DDL_BUCAP
DDL_BUCBP
DDL_BURA4
DDL_BURCA
DDL_BURCC
DDL_BURCH
DDL_BURCJ
DDL_BURCM
DDL_BURM1
DDL_BURM7
DDL_BURM9
DDL_BURMA
DDL_BURMS
DDL_BURP0
DDL_BURP1
DDL_BURP6
DDL_BURPS
DDL_BURTA
DDL_BURVG
DDL_CALBD
DDL_CALS4
DDL_CALS8
DDL_CAMC1
DDL_CAMJ8
DDL_CAMJD
DDL_CAMJE
DDL_CAMJJ
DDL_CAMJR
DDL_CAMLR
DDL_CARHZ
DDL_CAUSK
DDL_CAUVC
DDL_CERS4
DDL_CERS5
DDL_CHESB
DDL_CHLCH
DDL_CHLL2
DDL_CHLL3
DDL_CHLP8
DDL_CHLPB
DDL_CHLPD
DDL_CHLPM
DDL_CHLT3
DDL_CHLTE
DDL_CHRSD
DDL_CITBB
DDL_CLOAB
DDL_CLOB1
DDL_CLOB6
DDL_CLOB8
DDL_CLOBA
DDL_CLOBB
DDL_CLOBH
DDL_CLOBJ
DDL_CLOBK
DDL_CLOBL
DDL_CLOBM
DDL_CLOK1
DDL_CLOK5
DDL_CLONN
DDL_CLOPS
DDL_COLP3
DDL_COPPD
DDL_CORA7
DDL_CORDI
DDL_COREF
DDL_CORGB
DDL_CORGL
DDL_CORJK
DDL_CORU7
DDL_COXB1
DDL_COXBN
DDL_COXBR
DDL_COXBU
DDL_CUPMC
DDL_CUPNH
DDL_CUPPJ
DDL_CUPTR
DDL_DECAR
DDL_DEIGD
DDL_DEIRA
DDL_DELAS
DDL_DESAG
DDL_DESAP
DDL_DESDA
DDL_DESMR
DDL_DESPS
DDL_DESRM
DDL_DESVH
DDL_DESVV
DDL_DICNV
DDL_DINSH
DDL_ENTFA
DDL_ENTGA
DDL_ENTHA
DDL_ERWT9
DDL_ERYLH
DDL_FERNB
DDL_FINM2
DDL_FLAJ1
DDL_FLAPJ
DDL_FRACC
DDL_FRAP2
DDL_FRAT1
DDL_FRATF
DDL_FRATH
DDL_FRATN
DDL_FRATO
DDL_FRATT
DDL_FRATW
DDL_FUSNN
DDL_GEOKA
DDL_GEOLS
DDL_GEOSL
DDL_GEOSM
DDL_GEOTN
DDL_GEOUR
DDL_GLOC7
DDL_GLOVI
DDL_GLUOX
DDL_GRABC
DDL_GRAFK
DDL_HAEDU
DDL_HAEI8
DDL_HAEIE
DDL_HAEIG
DDL_HAEIN
DDL_HAEPS
DDL_HAES1
DDL_HALHL
DDL_HALOH
DDL_HAMD5
DDL_HELAH
DDL_HELHP
DDL_HELMI
DDL_HELP2
DDL_HELPH
DDL_HELPJ
DDL_HELPS
DDL_HELPY
DDL_HERA2
DDL_HERAR
DDL_HISS2
DDL_HYDCU
DDL_HYPNA
DDL_IDILO
DDL_JANMA
DDL_JANSC
DDL_KINRD
DDL_KOCRD
DDL_LACAC
DDL_LACCB
DDL_LACDA
DDL_LACDB
DDL_LACGA
DDL_LACH4
DDL_LACJO
DDL_LACLA
DDL_LACLM
DDL_LACLS
DDL_LACP3
DDL_LACPL
DDL_LARHH
DDL_LATSS
DDL_LAWIP
DDL_LEGPA
DDL_LEGPC
DDL_LEGPH
DDL_LEGPL
DDL_LEPBA
DDL_LEPBJ
DDL_LEPBL
DDL_LEPBP
DDL_LEPIC
DDL_LEPIN
DDL_LEUCK
DDL_LEUME
DDL_LEUMM
DDL_LEVBA
DDL_LIGS1
DDL_LIMF3
DDL_LIMRD
DDL_LISIN
DDL_LISMF
DDL_LISMO
DDL_LISW6
DDL_MACCJ
DDL_MAGMM
DDL_MAGSA
DDL_MANSM
DDL_MARMM
DDL_MARMS
DDL_MARN8
DDL_MARSD
DDL_METC4
DDL_METCA
DDL_METEP
DDL_METFK
DDL_METI4
DDL_METPB
DDL_METPP
DDL_METRJ
DDL_METS4
DDL_METSB
DDL_MICAN
DDL_MOOTA
DDL_MYCA1
DDL_MYCBO
DDL_MYCBP
DDL_MYCGI
DDL_MYCLE
DDL_MYCPA
DDL_MYCS2
DDL_MYCSJ
DDL_MYCSK
DDL_MYCSM
DDL_MYCSS
DDL_MYCTA
DDL_MYCTO
DDL_MYCTU
DDL_MYCUA
DDL_MYCVP
DDL_NATTJ
DDL_NEIG1
DDL_NEIG2
DDL_NEIMA
DDL_NEIMB
DDL_NEIMF
DDL_NITEC
DDL_NITEU
DDL_NITMU
DDL_NITOC
DDL_NITSB
DDL_NOCFA
DDL_NOSP7
DDL_NOSS1
DDL_NOVAD
DDL_OCEIH
DDL_OENOB
DDL_PAEAT
DDL_PARD8
DDL_PARL1
DDL_PARMW
DDL_PARP8
DDL_PARPJ
DDL_PARXL
DDL_PASMU
DDL_PECAS
DDL_PECCP
DDL_PEDPA
DDL_PELPB
DDL_PELPD
DDL_PELTS
DDL_PELUB
DDL_PETMO
DDL_PHOLL
DDL_PHOV8
DDL_POLAQ
DDL_POLNA
DDL_POLNS
DDL_POLSJ
DDL_PORG3
DDL_PORGI
DDL_PROA2
DDL_PROM0
DDL_PROM1
DDL_PROM2
DDL_PROM3
DDL_PROM5
DDL_PROM9
DDL_PROMA
DDL_PROMH
DDL_PROMM
DDL_PROMP
DDL_PROMS
DDL_PROMT
DDL_PSEA6
DDL_PSECP
DDL_PSEE4
DDL_PSELT
DDL_PSEMY
DDL_PSEPF
DDL_PSEPG
DDL_PSET1
DDL_PSEU5
DDL_PSYWF
DDL_RALPJ
DDL_RALSO
DDL_RHIME
DDL_RHOE4
DDL_RHOFT
DDL_RHOJR
DDL_RHOOB
DDL_RHOP5
DDL_RHOPB
DDL_RHORT
DDL_RHOS1
DDL_RICAE
DDL_RICAH
DDL_RICB8
DDL_RICBR
DDL_RICCK
DDL_RICCN
DDL_RICFE
DDL_RICM5
DDL_RICPR
DDL_RICPU
DDL_RICRO
DDL_RICRS
DDL_RICTY
DDL_RIPO1
DDL_ROSDO
DDL_RUEPO
DDL_RUEST
DDL_RUMCH
DDL_RUTMC
DDL_SACD2
DDL_SALPA
DDL_SALPK
DDL_SHEAM
DDL_SHEB2
DDL_SHEB8
DDL_SHEB9
DDL_SHEDO
DDL_SHEFN
DDL_SHEHH
DDL_SHELP
DDL_SHEON
DDL_SHEPA
DDL_SHEPC
DDL_SHEPW
DDL_SHESA
DDL_SHESH
DDL_SHESM
DDL_SHESR
DDL_SHESW
DDL_SHEWM
DDL_SINFN
DDL_SINMW
DDL_SODGM
DDL_SOLUE
DDL_SPHAL
DDL_SPHWW
DDL_STAA1
DDL_STAA2
DDL_STAA3
DDL_STAA8
DDL_STAA9
DDL_STAAB
DDL_STAAC
DDL_STAAE
DDL_STAAM
DDL_STAAN
DDL_STAAR
DDL_STAAS
DDL_STAAT
DDL_STAAW
DDL_STACT
DDL_STAEQ
DDL_STAES
DDL_STAHJ
DDL_STAS1
DDL_STRA1
DDL_STRA3
DDL_STRA5
DDL_STRAW
DDL_STRCO
DDL_STRE4
DDL_STREM
DDL_STRGC
DDL_STRGG
DDL_STRMU
DDL_STRP1
DDL_STRP2
DDL_STRP3
DDL_STRP4
DDL_STRP6
DDL_STRP8
DDL_STRPB
DDL_STRPC
DDL_STRPD
DDL_STRPF
DDL_STRPG
DDL_STRPI
DDL_STRPJ
DDL_STRPM
DDL_STRPN
DDL_STRPQ
DDL_STRPS
DDL_STRPZ
DDL_STRR6
DDL_STRS7
DDL_STRSV
DDL_STRT1
DDL_STRT2
DDL_STRTD
DDL_STRU0
DDL_STRZJ
DDL_STRZP
DDL_STRZT
DDL_SULDN
DDL_SULNB
DDL_SYNC1
DDL_SYNE7
DDL_SYNFM
DDL_SYNJA
DDL_SYNJB
DDL_SYNP2
DDL_SYNP6
DDL_SYNPW
DDL_SYNR3
DDL_SYNS3
DDL_SYNS9
DDL_SYNSC
DDL_SYNWW
DDL_SYNY3
DDL_THEAB
DDL_THEM4
DDL_THEMA
DDL_THEP1
DDL_THEP3
DDL_THEPX
DDL_THESQ
DDL_THET2
DDL_THET8
DDL_THEVB
DDL_THEYD
DDL_THIDA
DDL_TOLAT
DDL_TREDE
DDL_TREPA
DDL_TREPS
DDL_TRIEI
DDL_TRIV2
DDL_TROW8
DDL_TROWT
DDL_VEREI
DDL_VESOH
DDL_VIBA3
DDL_VIBC3
DDL_VIBCB
DDL_VIBCH
DDL_VIBCM
DDL_VIBPA
DDL_VIBVU
DDL_VIBVY
DDL_WIGBR
DDL_WOLPM
DDL_WOLPP
DDL_WOLSU
DDL_WOLTR
DDL_WOLWR
DDL_XANAC
DDL_XANP2
DDL_XYLFA
DDL_XYLFT
DDL_YERP3
DDL_YERPA
DDL_YERPB
DDL_YERPE
DDL_YERPG
DDL_YERPN
DDL_YERPP
DDL_YERPS
DDL_YERPY
DDL_ZYMMO
MUDD_CHLCV
MUDD_CHLMU
MUDD_CHLPN
MUDD_CHLTR
References
-
Ito, E. and Strominger, J.L.Enzymatic synthesis of the peptide in bacterial uridine nucleotides. II. Enzymatic synthesis and addition of D-alanyl-D-alanine.J. Biol. Chem. 237 : 2696-2703 (1962).
-
Neuhaus, F.C.Kinetic studies on D-Ala-D-Ala synthetase.Fed. Proc. 21 : 229 (1962).
-
van Heijenoort, J.Recent advances in the formation of the bacterial peptidoglycan monomer unit.Nat. Prod. Rep. 18 : 503-519 (2001). [PMID: 11699883]
[EC 6.3.2.4 created 1961, modified 2002]