EC - Glutamate—cysteine ligase

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IntEnz Enzyme Nomenclature


Accepted name:
glutamate—cysteine ligase
Other names:
γ-glutamyl-L-cysteine synthetase
γ-glutamylcysteine synthetase
γ-glutamylcysteinyl synthetase
Systematic name:
L-glutamate:L-cysteine γ-ligase (ADP-forming)



Can use L-aminohexanoate in place of glutamate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004357
CAS Registry Number: 9023-64-7
UniProtKB/Swiss-Prot: (337) [show] [UniProt]


  1. Mackinnon, C.M., Carter, P.E., Smyth, S.J., Dunbar, B. and Fothergill, J.E.
    Molecular-cloning of cDNA for human-complement component C1s - the complete amino-acid sequence.
    Eur. J. Biochem. 169 : 547-553 (1987). [PMID: 3500856]
  2. Snoke, J.E., Yanari, S. and Bloch, K.
    Synthesis of glutathione from γ-glutamylcysteine.
    J. Biol. Chem. 201 : 573-586 (1953). [PMID: 13061393]
  3. Mandeles, S. and Bloch, K.
    Enzymatic synthesis of γ-glutamylcysteine.
    J. Biol. Chem. 214 : 639-646 (1955).

[EC created 1961]