IntEnz

EC 6.3.2.10 - UDP-N-acetylmuramoyl-tripeptide—D-alanyl-D-alanine ligase

IntEnz Enzyme Nomenclature
EC 6.3.2.10

Names

Reactions

• 16085 [IUBMB]
  ATP

  ATP

  Name origin: UniProt - CHECKED (C)

  CHEBI:30616

  Formula: C10H12N5O13P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  +

  D-alanyl-D-alanine

  D-alanyl-D-alanine

  Name origin: UniProt - CHECKED (C)

  CHEBI:57822

  Formula: C6H12N2O3
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-L-lysine

  UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine

  Name origin: UniProt - CHECKED (C)

  CHEBI:83903

  Formula: C34H52N7O24P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  =

  ADP

  ADP

  Name origin: UniProt - CHECKED (C)

  CHEBI:456216

  Formula: C10H12N5O10P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  phosphate

  phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:43474

  Formula: HO4P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine

  UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine

  Name origin: UniProt - CHECKED (C)

  CHEBI:70758

  Formula: C40H62N9O26P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  
• 28374
  ATP

  ATP

  Name origin: UniProt - CHECKED (C)

  CHEBI:30616

  Formula: C10H12N5O13P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  +

  D-alanyl-D-alanine

  D-alanyl-D-alanine

  Name origin: UniProt - CHECKED (C)

  CHEBI:57822

  Formula: C6H12N2O3
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminoheptanedioate

  UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate

  Name origin: UniProt - CHECKED (C)

  CHEBI:83905

  Formula: C35H51N7O26P2
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  =

  ADP

  ADP

  Name origin: UniProt - CHECKED (C)

  CHEBI:456216

  Formula: C10H12N5O10P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  phosphate

  phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:43474

  Formula: HO4P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine

  UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine

  Name origin: UniProt - CHECKED (C)

  CHEBI:61386

  Formula: C41H61N9O28P2
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

Comments:

Involved with EC 6.3.2.4 (D-alanine—D-alanine ligase), EC 6.3.2.7 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—L-lysine ligase) or EC 6.3.2.13 (UDP-N-acetylmuramoylalanyl-D-glutamate—2,6-diaminopimelate ligase), EC 6.3.2.8 (UDP-N-acetylmuramate—L-alanine ligase) and EC 6.3.2.9 (UDP-N-acetylmuramoylalanine—D-glutamate ligase) in the synthesis of a cell-wall peptide. This enzyme also catalyses the reaction when the C-terminal residue of the tripeptide is meso-2,6-diaminoheptanedioate (acylated at its L-centre), linking the D-Ala—D-Ala to the carboxy group of the L-centre. This activity was previously attributed to EC 6.3.2.15, which has since been deleted.

Links to other databases

References

1. Ito, E. and Strominger, J.L.
   Enzymatic synthesis of the peptide in bacterial uridine nucleotides. II. Enzymatic synthesis and addition of D-alanyl-D-alanine.
   J. Biol. Chem. 237 : 2696-2703 (1962).
2. van Heijenoort, J.
   Recent advances in the formation of the bacterial peptidoglycan monomer unit.
   Nat. Prod. Rep. 18 : 503-519 (2001). [PMID: 11699883]

[EC 6.3.2.10 created 1965, modified 2002]