EC 6.3.2.10 - UDP-N-acetylmuramoyl-tripeptide—D-alanyl-D-alanine ligase

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IntEnz Enzyme Nomenclature
EC 6.3.2.10

Names

Accepted name:
UDP-N-acetylmuramoyl-tripeptide—D-alanyl-D-alanine ligase
Other names:
MurF synthetase
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase
UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase
UDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligase
UDPacetylmuramoylpentapeptide synthetase
uridine diphosphoacetylmuramoylpentapeptide synthetase
UDP-MurNAc-pentapeptide synthetase
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate—D-alanyl-D-alanine ligase
UDP-N-acetylmuramoylalanine-D-glutamyl-lysine—D-alanyl-D-alanine ligase
Systematic name:
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine:D-alanyl-D-alanine ligase (ADP-forming)

Reaction

Comments:

Involved with EC 6.3.2.4 (D-alanine—D-alanine ligase), EC 6.3.2.7 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—L-lysine ligase) or EC 6.3.2.13 (UDP-N-acetylmuramoylalanyl-D-glutamate—2,6-diaminopimelate ligase), EC 6.3.2.8 (UDP-N-acetylmuramate—L-alanine ligase) and EC 6.3.2.9 (UDP-N-acetylmuramoylalanine—D-glutamate ligase) in the synthesis of a cell-wall peptide. This enzyme also catalyses the reaction when the C-terminal residue of the tripeptide is meso-2,6-diaminoheptanedioate (acylated at its L-centre), linking the D-Ala—D-Ala to the carboxy group of the L-centre. This activity was previously attributed to EC 6.3.2.15, which has since been deleted.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047480 , GO:0008766
CAS Registry Number: 9023-60-3
UniProtKB/Swiss-Prot: (16) [show] [UniProt]

References

  1. Ito, E. and Strominger, J.L.
    Enzymatic synthesis of the peptide in bacterial uridine nucleotides. II. Enzymatic synthesis and addition of D-alanyl-D-alanine.
    J. Biol. Chem. 237 : 2696-2703 (1962).
  2. van Heijenoort, J.
    Recent advances in the formation of the bacterial peptidoglycan monomer unit.
    Nat. Prod. Rep. 18 : 503-519 (2001). [PMID: 11699883]

[EC 6.3.2.10 created 1965, modified 2002]