EC 18.104.22.168 - UDP-N-acetylmuramoyl-tripeptide—D-alanyl-D-alanine ligase
IntEnz Enzyme Nomenclature
uridine diphosphoacetylmuramoylpentapeptide synthetase
16085 [IUBMB]ATPATPName origin: UniProt - CHECKED (C)Formula: C10H12N5O13P3
Charge: -4ChEBI compound status: CHECKED (C)D-alanyl-D-alanineD-alanyl-D-alanineName origin: UniProt - CHECKED (C)Formula: C6H12N2O3
Charge: 0ChEBI compound status: CHECKED (C)UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-L-lysineUDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysineName origin: UniProt - CHECKED (C)Formula: C34H52N7O24P2
Charge: -3ChEBI compound status: CHECKED (C)=ADPADPName origin: UniProt - CHECKED (C)Formula: C10H12N5O10P2
Charge: -3ChEBI compound status: CHECKED (C)H+H(+)Name origin: UniProt - CHECKED (C)Formula: H
Charge: 1ChEBI compound status: CHECKED (C)phosphatephosphateName origin: UniProt - CHECKED (C)Formula: HO4P
Charge: -2ChEBI compound status: CHECKED (C)
Involved with EC 22.214.171.124 (D-alanine—D-alanine ligase), EC 126.96.36.199 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—L-lysine ligase) or EC 188.8.131.52 (UDP-N-acetylmuramoylalanyl-D-glutamate—2,6-diaminopimelate ligase), EC 184.108.40.206 (UDP-N-acetylmuramate—L-alanine ligase) and EC 220.127.116.11 (UDP-N-acetylmuramoylalanine—D-glutamate ligase) in the synthesis of a cell-wall peptide. This enzyme also catalyses the reaction when the C-terminal residue of the tripeptide is meso-2,4-diaminoheptanedioate (acylated at its L-centre), linking the D-Ala—D-Ala to the carboxy group of the L-centre. This activity was previously attributed to EC 18.104.22.168, which has since been deleted.
Links to other databases
Enzymatic synthesis of the peptide in bacterial uridine nucleotides. II. Enzymatic synthesis and addition of D-alanyl-D-alanine.J. Biol. Chem. 237: 2696-2703 (1962).
Recent advances in the formation of the bacterial peptidoglycan monomer unit.Nat. Prod. Rep. 18: 503-519 (2001). [PMID: 11699883]
[EC 22.214.171.124 created 1965, modified 2002]