EC 6 - Ligases
EC 6.3 - Forming carbon-nitrogen bonds
EC 6.3.2 - Acid—amino-acid ligases (peptide synthases)
EC 6.3.2.10 - UDP-N-acetylmuramoyl-tripeptide—D-alanyl-D-alanine ligase
IntEnz Enzyme Nomenclature
EC 6.3.2.10
Names
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase
UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase
UDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligase
UDPacetylmuramoylpentapeptide synthetase
uridine diphosphoacetylmuramoylpentapeptide synthetase
UDP-MurNAc-pentapeptide synthetase
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate—D-alanyl-D-alanine ligase
UDP-N-acetylmuramoylalanine-D-glutamyl-lysine—D-alanyl-D-alanine ligase
Reaction
- ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine
Comments:
Involved with EC 6.3.2.4 (D-alanine—D-alanine ligase), EC 6.3.2.7 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—L-lysine ligase) or EC 6.3.2.13 (UDP-N-acetylmuramoylalanyl-D-glutamate—2,6-diaminopimelate ligase), EC 6.3.2.8 (UDP-N-acetylmuramate—L-alanine ligase) and EC 6.3.2.9 (UDP-N-acetylmuramoylalanine—D-glutamate ligase) in the synthesis of a cell-wall peptide. This enzyme also catalyses the reaction when the C-terminal residue of the tripeptide is meso-2,6-diaminoheptanedioate (acylated at its L-centre), linking the D-Ala—D-Ala to the carboxy group of the L-centre. This activity was previously attributed to EC 6.3.2.15, which has since been deleted.
Links to other databases
References
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Enzymatic synthesis of the peptide in bacterial uridine nucleotides. II. Enzymatic synthesis and addition of D-alanyl-D-alanine.J. Biol. Chem. 237 : 2696-2703 (1962).
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Recent advances in the formation of the bacterial peptidoglycan monomer unit.Nat. Prod. Rep. 18 : 503-519 (2001). [PMID: 11699883]
[EC 6.3.2.10 created 1965, modified 2002]