EC 6.3.1.10 - Adenosylcobinamide-phosphate synthase

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IntEnz Enzyme Nomenclature
EC 6.3.1.10

Names

Accepted name:
adenosylcobinamide-phosphate synthase
Other names:
AdoCbi-P synthase
CbiB
cobyric acid synthase
Systematic name:
adenosylcobyric acid:(R)-1-aminopropan-2-yl phosphate ligase (ADP-forming)

Reactions

Comments:

This enzyme forms part of the anaerobic cobalamin biosynthesis pathway. One of the substrates for this reaction, (R)-1-aminopropan-2-yl phosphate, is produced by CobD (EC 4.1.1.81, threonine phosphate decarboxylase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0043757

References

  1. Cheong, C.G., Bauer, C.B., Brushaber, K.R., Escalante-Semerena, J.C. and Rayment, I.
    Three-dimensional structure of the L-threonine-O-3-phosphate decarboxylase (CobD) enzyme from Salmonella enterica.
    Biochemistry 41: 4798-4808 (2002). [PMID: 11939774]
  2. Warren, M.J., Raux, E., Schubert, H.L. and Escalante-Semerena, J.C.
    The biosynthesis of adenosylcobalamin (vitamin B12).
    Nat. Prod. Rep. 19: 390-412 (2002). [PMID: 12195810]

[EC 6.3.1.10 created 2004]