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EC 6.3.1.10 - Adenosylcobinamide-phosphate synthase

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IntEnz Enzyme Nomenclature
EC 6.3.1.10

Names

Accepted name:

adenosylcobinamide-phosphate synthase

Other names:

AdoCbi-P synthase
CbiB
cobyric acid synthase

Systematic name:

adenosylcobyric acid:(R)-1-aminopropan-2-yl phosphate ligase (ADP-forming)

Reactions

21896 [IUBMB]

(R)-1-aminopropan-2-yl phosphate

(R)-1-aminopropan-2-yl phosphate

Name origin: UniProt - CHECKED (C)

CHEBI:58563

Formula: C3H9NO4P
Charge: -1

ChEBI compound status: CHECKED (C)

+

adenosylcob(III)yrate

adenosylcob(III)yrate

Name origin: UniProt - CHECKED (C)

CHEBI:58504

Formula: C55H76CoN15O11
Charge: 0

ChEBI compound status: CHECKED (C)

+

ATP

ATP

Name origin: UniProt - CHECKED (C)

CHEBI:30616

Formula: C10H12N5O13P3
Charge: -4

ChEBI compound status: CHECKED (C)

=

adenosylcob(III)inamide phosphate

adenosylcob(III)inamide phosphate

Name origin: UniProt - CHECKED (C)

CHEBI:58502

Formula: C58H83CoN16O14P
Charge: -1

ChEBI compound status: CHECKED (C)

+

ADP

ADP

Name origin: UniProt - CHECKED (C)

CHEBI:456216

Formula: C10H12N5O10P2
Charge: -3

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

+

phosphate

phosphate

Name origin: UniProt - CHECKED (C)

CHEBI:43474

Formula: HO4P
Charge: -2

ChEBI compound status: CHECKED (C)
12572 [IUBMB]

(R)-1-aminopropan-2-ol

(R)-1-aminopropan-2-ol

Name origin: UniProt - CHECKED (C)

CHEBI:42677

Formula: C3H10NO
Charge: 1

ChEBI compound status: CHECKED (C)

+

adenosylcob(III)yrate

adenosylcob(III)yrate

Name origin: UniProt - CHECKED (C)

CHEBI:58504

Formula: C55H76CoN15O11
Charge: 0

ChEBI compound status: CHECKED (C)

+

ATP

ATP

Name origin: UniProt - CHECKED (C)

CHEBI:30616

Formula: C10H12N5O13P3
Charge: -4

ChEBI compound status: CHECKED (C)

=

adenosylcob(III)inamide

adenosylcob(III)inamide

Name origin: UniProt - CHECKED (C)

CHEBI:2480

Formula: C58H84CoN16O11
Charge: 1

ChEBI compound status: CHECKED (C)

+

ADP

ADP

Name origin: UniProt - CHECKED (C)

CHEBI:456216

Formula: C10H12N5O10P2
Charge: -3

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

+

phosphate

phosphate

Name origin: UniProt - CHECKED (C)

CHEBI:43474

Formula: HO4P
Charge: -2

ChEBI compound status: CHECKED (C)

Comments:

This enzyme forms part of the anaerobic cobalamin biosynthesis pathway. One of the substrates for this reaction, (R)-1-aminopropan-2-yl phosphate, is produced by CobD (EC 4.1.1.81, threonine phosphate decarboxylase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway

Structural data: CSA , EC2PDB

Gene Ontology: GO:0043757

References

Cheong, C.G., Bauer, C.B., Brushaber, K.R., Escalante-Semerena, J.C. and Rayment, I.

Three-dimensional structure of the L-threonine-O-3-phosphate decarboxylase (CobD) enzyme from Salmonella enterica.

Biochemistry 41: 4798-4808 (2002). [PMID: 11939774]
Warren, M.J., Raux, E., Schubert, H.L. and Escalante-Semerena, J.C.

The biosynthesis of adenosylcobalamin (vitamin B₁₂).

Nat. Prod. Rep. 19: 390-412 (2002). [PMID: 12195810]

[EC 6.3.1.10 created 2004]

EC 6 - Ligases