EC 6 - Ligases
EC 6.3 - Forming carbon-nitrogen bonds
EC 6.3.1 - Acid—ammonia (or amine) ligases (amide synthases)
EC 6.3.1.10 - Adenosylcobinamide-phosphate synthase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 6.3.1.10
Names
Accepted name:
adenosylcobinamide-phosphate synthase
Other
names:
AdoCbi-P synthase
CbiB
cobyric acid synthase
CbiB
cobyric acid synthase
Systematic name:
adenosylcobyric acid:(R)-1-aminopropan-2-yl phosphate ligase (ADP-forming)
Reactions
- (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate
- (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide
Comments:
This enzyme forms part of the anaerobic cobalamin biosynthesis pathway. One of the substrates for this reaction, (R)-1-aminopropan-2-yl phosphate, is produced by CobD (EC 4.1.1.81, threonine phosphate decarboxylase).
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Gene Ontology:
GO:0043757
References
-
Three-dimensional structure of the L-threonine-O-3-phosphate decarboxylase (CobD) enzyme from Salmonella enterica.Biochemistry 41 : 4798-4808 (2002). [PMID: 11939774]
-
The biosynthesis of adenosylcobalamin (vitamin B12).Nat. Prod. Rep. 19 : 390-412 (2002). [PMID: 12195810]
[EC 6.3.1.10 created 2004]