EC 6.2.1.61 - Salicylate—[aryl-carrier protein] ligase

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IntEnz Enzyme Nomenclature
EC 6.2.1.61

Names

Accepted name:
salicylate—[aryl-carrier protein] ligase
Systematic name:
salicylate:holo-[non-ribosomal peptide synthase] ligase

Reaction

Comments:

The enzyme catalyses the activation of salicylate to (salicyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of an aryl-carrier protein, which is often a domain of a larger non-ribosimal peptide synthase. The PmsE enzyme is involved in pseudomonine biosynthesis and transfers the activated salicylate first to itself, and then to a PmsG protein. The PchD enzyme is involved in pyochelin biosynthesis and transfers the activated salicylate directly to the PchE protein.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Quadri, L. E., Keating, T. A., Patel, H. M., Walsh, C. T.
    Assembly of the Pseudomonas aeruginosa nonribosomal peptide siderophore pyochelin: In vitro reconstitution of aryl-4, 2-bisthiazoline synthetase activity from PchD, PchE, and PchF.
    Biochemistry 38 : 14941-14954 (1999). [PMID: 10555976]
  2. Sattely, E. S., Walsh, C. T.
    A latent oxazoline electrophile for N-O-C bond formation in pseudomonine biosynthesis.
    J. Am. Chem. Soc. 130 : 12282-12284 (2008). [PMID: 18710233]

[EC 6.2.1.61 created 2019]