EC 6.2.1.43 - 2-hydroxy-7-methoxy-5-methyl-1-naphthoate—CoA ligase

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IntEnz Enzyme Nomenclature
EC 6.2.1.43

Names

Accepted name:
2-hydroxy-7-methoxy-5-methyl-1-naphthoate—CoA ligase
Other name:
NcsB2
Systematic name:
2-hydroxy-7-methoxy-5-methyl-1-naphthoate:CoA ligase

Reaction

Comments:

The enzyme from the bacterium Streptomyces carzinostaticus is involved in the attachment of the 2-hydroxy-7-methoxy-5-methyl-1-naphthoate moiety of the antibiotic neocarzinostatin. In vitro the enzyme also catalyses the activation of other 1-naphthoic acid analogues, e.g. 2-hydroxy-5-methyl-1-naphthoate or 2,7-dihydroxy-5-methyl-1-naphthoate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Cooke, H. A., Zhang, J., Griffin, M. A., Nonaka, K., Van Lanen, S. G., Shen, B., Bruner, S. D.
    Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.
    J. Am. Chem. Soc. 129 : 7728-7729 (2007). [PMID: 17539640]

[EC 6.2.1.43 created 2014]