EC 6.2.1.35 - Acetate—[acyl-carrier protein] ligase

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IntEnz Enzyme Nomenclature
EC 6.2.1.35

Names

Accepted name:
acetate—[acyl-carrier protein] ligase
Other names:
HS-acyl-carrier protein:acetate ligase
[acyl-carrier protein]:acetate ligase
MadH
ACP-SH:acetate ligase
Systematic name:
acetate:[acyl-carrier-protein] ligase (AMP-forming)

Reaction

Comments:

This enzyme, from the anaerobic bacterium Malonomonas rubra, is a component of the multienzyme complex EC 7.2.4.4, biotin-dependent malonate decarboxylase. The enzyme uses the energy from hydrolysis of ATP to convert the thiol group of the acyl-carrier-protein-bound 2'-(5-phosphoribosyl)-3'-dephospho-CoA prosthetic group into its acetyl thioester [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Hilbi, H., Dehning, I., Schink, B. and Dimroth, P.
    Malonate decarboxylase of Malonomonas rubra, a novel type of biotin-containing acetyl enzyme.
    Eur. J. Biochem. 207 : 117-123 (1992). [PMID: 1628643]
  2. Berg, M., Hilbi, H. and Dimroth, P.
    The acyl carrier protein of malonate decarboxylase of Malonomonas rubra contains 2'-(5"-phosphoribosyl)-3'-dephosphocoenzyme A as a prosthetic group.
    Biochemistry 35 : 4689-4696 (1996). [PMID: 8664258]
  3. Berg, M., Hilbi, H. and Dimroth, P.
    Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function.
    Eur. J. Biochem. 245 : 103-115 (1997). [PMID: 9128730]
  4. Dimroth, P. and Hilbi, H.
    Enzymic and genetic basis for bacterial growth on malonate.
    Mol. Microbiol. 25 : 3-10 (1997). [PMID: 11902724]

[EC 6.2.1.35 created 2008, modified 2018]