EC - Long-chain-fatty-acid—CoA ligase

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IntEnz Enzyme Nomenclature


Accepted name:
long-chain-fatty-acid—CoA ligase
Other names:
LCFA synthetase
acyl coenzyme A synthetase
acyl-CoA ligase
acyl-CoA synthetase
acyl-activating enzyme
acyl-coenzyme A ligase
arachidonyl-CoA synthetase
fatty acid CoA ligase
fatty acid elongase
fatty acid thiokinase (long chain)
fatty acyl-coenzyme A synthetase
lignoceroyl-CoA synthase
long chain fatty acyl-CoA synthetase
long-chain acyl CoA synthetase
long-chain acyl-CoA synthetase I
long-chain acyl-CoA synthetase II
long-chain acyl-coenzyme A synthetase
long-chain fatty acyl coenzyme A synthetase
oleoyl-CoA synthetase
palmitoyl coenzyme A synthetase
palmitoyl-CoA ligase
palmitoyl-CoA synthase
pristanoyl-CoA synthetase
stearoyl-CoA synthetase
Systematic name:
long-chain fatty acid:CoA ligase (AMP-forming)



Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. The liver enzyme acts on acids from C6 to C20; that from brain shows high activity up to C24.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Protein domains and families: PROSITE:PDOC00427
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004467
CAS Registry Number: 9013-18-7
UniProtKB/Swiss-Prot: (96) [show] [UniProt]


  1. Bakken, A.M. and Farstad, M.
    Identical subcellular distribution of palmitoyl-CoA and arachidonoyl-CoA synthetase activities in human blood platelets.
    Biochem. J. 261 : 71-76 (1989). [PMID: 2528345]
  2. Hosaka, K., Mishima, M., Tanaka, T., Kamiryo, T. and Numa, S.
    Acyl-coenzyme-A synthetase I from Candida lipolytica. Purification, properties and immunochemical studies.
    Eur. J. Biochem. 93 : 197-203 (1979). [PMID: 108099]
  3. Nagamatsu, K., Soeda, S., Mori, M. and Kishimoto, Y.
    Lignoceroyl-coenzyme A synthetase from developing rat brain: partial purification, characterization and comparison with palmitoyl-coenzyme A synthetase activity and liver enzyme.
    Biochim. Biophys. Acta 836 : 80-88 (1985). [PMID: 3161545]
  4. Tanaka, T., Hosaka, K., Hoshimaru, M. and Numa, S.
    Purification and properties of long-chain acyl-coenzyme-A synthetase from rat liver.
    Eur. J. Biochem. 98 : 165-172 (1979). [PMID: 467438]

[EC created 1961, modified 1989, modified 2011]