EC - Long-chain-fatty-acid—[acyl-carrier-protein] ligase

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IntEnz Enzyme Nomenclature


Accepted name:
long-chain-fatty-acid—[acyl-carrier-protein] ligase
Other names:
acyl-ACP synthetase [ambiguous]
acyl-[acyl carrier protein] synthetase
acyl-[acyl-carrier-protein] synthetase [ambiguous]
acyl-acyl carrier protein synthetase [ambiguous]
stearoyl-ACP synthetase
long-chain-fatty-acid:[acyl-carrier-protein] ligase (AMP-forming)
Systematic name:
long-chain-fatty-acid:[acyl-carrier protein] ligase (AMP-forming)



The enzyme ligates long chain fatty acids (with aliphatic chain of 13-22 carbons) to an acyl-carrier protein. Not identical with EC long-chain-fatty-acid—CoA ligase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008922
CAS Registry Number: 77322-37-3
UniProtKB/Swiss-Prot: (69) [show] [UniProt]


  1. Ray, T.K. and Cronan, J.E., Jr.
    Activation of long chain fatty acids with acyl carrier protein: demonstration of a new enzyme, acyl-acyl carrier protein synthetase, in Escherichia coli.
    Proc. Natl. Acad. Sci. USA 73 : 4374-4378 (1976). [PMID: 794875]
  2. Kaczmarzyk, D., Fulda, M.
    Fatty acid activation in cyanobacteria mediated by acyl-acyl carrier protein synthetase enables fatty acid recycling.
    Plant Physiol. 152 : 1598-1610 (2010). [PMID: 20061450]

[EC created 1986]