IntEnz

EC 6.2.1.13 - Acetate—CoA ligase (ADP-forming)

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IntEnz Enzyme Nomenclature
EC 6.2.1.13

Names

Accepted name:

acetate—CoA ligase (ADP-forming)

Other names:

acetate thiokinase
acetyl coenzyme A synthetase (adenosine diphosphate-forming)
acetyl-CoA synthetase (ADP-forming)

Systematic name:

acetate:CoA ligase (ADP-forming)

Reactions

15081 [IUBMB]

acetate

acetate

Name origin: UniProt - CHECKED (C)

CHEBI:30089

Formula: C2H3O2
Charge: -1

ChEBI compound status: CHECKED (C)

+

ATP

ATP

Name origin: UniProt - CHECKED (C)

CHEBI:30616

Formula: C10H12N5O13P3
Charge: -4

ChEBI compound status: CHECKED (C)

+

CoA

CoA

Name origin: UniProt - CHECKED (C)

CHEBI:57287

Formula: C21H32N7O16P3S
Charge: -4

ChEBI compound status: CHECKED (C)

=

acetyl-CoA

acetyl-CoA

Name origin: UniProt - CHECKED (C)

CHEBI:57288

Formula: C23H34N7O17P3S
Charge: -4

ChEBI compound status: CHECKED (C)

+

ADP

ADP

Name origin: UniProt - CHECKED (C)

CHEBI:456216

Formula: C10H12N5O10P2
Charge: -3

ChEBI compound status: CHECKED (C)

+

phosphate

phosphate

Name origin: UniProt - CHECKED (C)

CHEBI:43474

Formula: HO4P
Charge: -2

ChEBI compound status: CHECKED (C)
29843

ATP

ATP

Name origin: UniProt - CHECKED (C)

CHEBI:30616

Formula: C10H12N5O13P3
Charge: -4

ChEBI compound status: CHECKED (C)

+

CoA

CoA

Name origin: UniProt - CHECKED (C)

CHEBI:57287

Formula: C21H32N7O16P3S
Charge: -4

ChEBI compound status: CHECKED (C)

+

propanoate

propanoate

Name origin: UniProt - CHECKED (C)

CHEBI:17272

Formula: C3H5O2
Charge: -1

ChEBI compound status: CHECKED (C)

=

ADP

ADP

Name origin: UniProt - CHECKED (C)

CHEBI:456216

Formula: C10H12N5O10P2
Charge: -3

ChEBI compound status: CHECKED (C)

+

phosphate

phosphate

Name origin: UniProt - CHECKED (C)

CHEBI:43474

Formula: HO4P
Charge: -2

ChEBI compound status: CHECKED (C)

+

propanoyl-CoA

propanoyl-CoA

Name origin: UniProt - CHECKED (C)

CHEBI:57392

Formula: C24H36N7O17P3S
Charge: -4

ChEBI compound status: CHECKED (C)

Comments:

Also acts on propanoate and, very slowly, on butanoate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway

Structural data: CSA , EC2PDB

Gene Ontology: GO:0043758

CAS Registry Number: 62009-85-2

UniProtKB/Swiss-Prot:

O29057

ACD1_ARCFU

O28341

ACD2_ARCFU

E7FI45

ACDA1_PYRFU

Q8U3D6

ACDA2_PYRFU

E7FHP1

ACDB1_PYRFU

Q8TZY8

ACDB2_PYRFU

Q58010

ACD_METJA

References

Reeves, R.E., Warren, L.G., Susskind, B. and Lo, H.-S.

An energy-conserving pyruvate-to-acetate pathway in Entamoeba histolytica. Pyruvate synthase and a new acetate thiokinase.

J. Biol. Chem. 252: 726-731 (1977). [PMID: 13076]

[EC 6.2.1.13 created 1978]

EC 6 - Ligases