EC - 4-coumarate—CoA ligase

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IntEnz Enzyme Nomenclature


Accepted name:
4-coumarate—CoA ligase
Other names:
4-coumarate:coenzyme A ligase
4-coumaroyl-CoA synthetase
4-coumaryl-CoA synthetase
p-coumaroyl CoA ligase
p-coumaryl coenzyme A synthetase
p-coumaryl-CoA ligase
p-coumaryl-CoA synthetase
p-hydroxycinnamic acid:CoA ligase
p-hydroxycinnamoyl coenzyme A synthetase
caffeolyl coenzyme A synthetase
feruloyl CoA ligase
feruloyl coenzyme A synthetase
hydroxycinnamate:CoA ligase
hydroxycinnamoyl CoA synthetase
sinapoyl coenzyme A synthetase
4-coumaroyl-CoA synthase
Systematic name:
4-coumarate:CoA ligase (AMP-forming)


Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00427
Structural data: CSA , EC2PDB
Gene Ontology: GO:0016207
CAS Registry Number: 37332-51-7
UniProtKB/Swiss-Prot: (25) [show] [UniProt]


  1. Gross, G.G. and Zenk, M.H.
    Isolation and properties of hydroxycinnamate: CoA ligase from lignifying tissue of Forsythia.
    Eur. J. Biochem. 42: 453-459 (1974). [PMID: 4364250]
  2. Lindl, T., Kreuzaler, F. and Hahlbrock, F.
    Synthesis of p-coumaroyl coenzyme A with a partially purified p-coumarate:CoA ligase from cell suspension cultures of soybean (Glycine max).
    Biochim. Biophys. Acta 302: 457-464 (1973). [PMID: 4699252]

[EC created 1976]