EC - Acetate—CoA ligase

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IntEnz Enzyme Nomenclature


Accepted name:
acetate—CoA ligase
Other names:
acetate thiokinase
acetic thiokinase
acetyl CoA ligase
acetyl CoA synthase
acetyl activating enzyme
acetyl coenzyme A synthetase
acetyl-CoA synthetase
acetyl-coenzyme A synthase
acyl-activating enzyme
short chain fatty acyl-CoA synthetase
short-chain acyl-coenzyme A synthetase
Systematic name:
acetate:CoA ligase (AMP-forming)



Also acts on propanoate and propenoate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00427
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003987
CAS Registry Number: 9012-31-1
UniProtKB/Swiss-Prot: (224) [show] [UniProt]


  1. Chou, T.C. and Lipmann, F.
    Separation of acetyl transfer enzymes in pigeon liver extract.
    J. Biol. Chem. 196 : 89-103 (1952).
  2. Eisenberg, M.A.
    The acetate-activating enzyme of Rhodospirillum rubrum.
    Biochim. Biophys. Acta 16 : 58-65 (1955).
  3. Hele, P.
    The acetate activating enzyme of beef heart.
    J. Biol. Chem. 206 : 671-676 (1954).
  4. Millerd, A. and Bonner, J.
    Acetate activation and acetoacetate formation in plant systems.
    Arch. Biochem. Biophys. 49 : 343-355 (1954).

[EC created 1961]