EC 6.1.2.2 - Nebramycin 5' synthase

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IntEnz Enzyme Nomenclature
EC 6.1.2.2

Names

Accepted name:
nebramycin 5' synthase
Other names:
TobZ [ambiguous]
tobramycin carbamoyltransferase
Systematic name:
tobramycin:carbamoyl phosphate ligase (AMP,phosphate-forming)

Reactions

Cofactor

Comments:

Requires Fe(III). The enzyme from the bacterium Streptoalloteichus tenebrarius catalyses the activation of carbamoyl phosphate to O-carbamoyladenylate and the subsequent carbamoylation of kanamycin and tobramycin.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Parthier, C., Gorlich, S., Jaenecke, F., Breithaupt, C., Brauer, U., Fandrich, U., Clausnitzer, D., Wehmeier, U. F., Bottcher, C., Scheel, D., Stubbs, M. T.
    The O-carbamoyltransferase TobZ catalyzes an ancient enzymatic reaction.
    Angew. Chem. Int. Ed. Engl. 51 : 4046-4052 (2012). [PMID: 22383337]

[EC 6.1.2.2 created 2014]