EC 220.127.116.11 - D-alanine—poly(phosphoribitol) ligase
IntEnz Enzyme Nomenclature
D-alanine-membrane acceptor ligase
D-alanine: membrane acceptor ligase
- ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate)
A thioester bond is formed transiently between D-alanine and the sulfhydryl group of the 4'-phosphopantetheine prosthetic group of D-alanyl carrier protein during the activation of the alanine. Involved in the synthesis of teichoic acids.
Links to other databases
The enzymic activation of D-alanine.Biochem. J. 75: 579 (1960).
D-Alanine:membrane acceptor ligase from Lactobacillus casei.J. Biol. Chem. 246: 6136-6143 (1971). [PMID: 4399593]
Incorporation of D-alanine into lipoteichoic acid and wall teichoic acid in Bacillus subtilis.J. Biol. Chem. 270: 15598-15606 (1995). [PMID: 7797557]
Role of D-alanyl carrier protein in the biosynthesis of D-alanyl-lipoteichoic acid.J. Bacteriol. 176: 681-690 (1994). [PMID: 8300523]
The D-alanyl carrier protein in Lactobacillus casei: cloning, sequencing and expression of dltC.J. Bacteriol. 178: 3869-3876 (1996). [PMID: 8682792]
[EC 18.104.22.168 created 1965, modified 2001]