EC - Methionine—tRNA ligase

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IntEnz Enzyme Nomenclature


Accepted name:
methionine—tRNA ligase
Other names:
methionine translase
methionyl-tRNA synthetase
methionyl-transfer RNA synthetase
methionyl-transfer ribonucleate synthetase
methionyl-transfer ribonucleic acid synthetase
Systematic name:
L-methionine:tRNAMet ligase (AMP-forming)



In those organisms producing N-formylmethionyl-tRNAfMet for translation initiation, this enzyme also recognizes the initiator tRNAfMet and catalyses the formation of L-methionyl-tRNAfMet, the substrate for EC, methionyl—tRNA formyltransferase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00161
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004825
CAS Registry Number: 9033-22-1
UniProtKB/Swiss-Prot: (500) [show] [UniProt]


  1. Bergmann, F.H., Berg, P. and Dieckmann, M.
    The enzymic synthesis of amino acyl derivatives of ribonucleic acid. II. The preparation of leucyl-, valyl-, isoleucyl- and methionyl ribonucleic acid synthetases from Escherichia coli.
    J. Biol. Chem. 236 : 1735-1740 (1961).
  2. Lee, C.P., Dyson, M.R., Mandal, N., Varshney, U., Bahramian, B. and RajBhandary, U.L.
    Striking effects of coupling mutations in the acceptor stem on recognition of tRNAs by Escherichia coli Met-tRNA synthetase and Met-tRNA transformylase.
    Proc. Natl. Acad. Sci. USA 89 : 9262-9266 (1992). [PMID: 1409632]

[EC created 1961, modified 2002]