EC - DNA topoisomerase (ATP-hydrolysing)

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IntEnz Enzyme Nomenclature


Accepted name:
DNA topoisomerase (ATP-hydrolysing)
Other names:
DNA topoisomerase II
DNA gyrase
type II DNA topoisomerase
Systematic name:
DNA topoisomerase (ATP-hydrolysing)



The enzyme can introduce negative superhelical turns into double-stranded circular DNA. One unit has nicking-closing activity, and another catalyses super-twisting and hydrolysis of ATP (cf. EC DNA topoisomerase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00160
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003918
UniProtKB/Swiss-Prot: (393) [show] [UniProt]


  1. Gellert, M.
    DNA topoisomerases.
    Annu. Rev. Biochem. 50 : 879-910 (1981). [PMID: 6267993]

[EC created 1984 as, transferred 2018 to EC]