EC 5.5.1.16 - Halimadienyl-diphosphate synthase

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IntEnz Enzyme Nomenclature
EC 5.5.1.16

Names

Accepted name:
halimadienyl-diphosphate synthase
Other names:
Rv3377c
halimadienyl diphosphate synthase
tuberculosinol diphosphate synthase
tuberculosinyl-diphosphate lyase (decyclizing)
Systematic name:
tuberculosinyl-diphosphate lyase (ring-opening)

Reaction

Cofactor

Comments:

Requires Mg2+ for activity. This enzyme is found in pathogenic prokaryotes such as Mycobacterium tuberculosis but not in non-pathogens such as Mycobacterium smegmatis so may play a role in pathogenicity. The product of the reaction is subsequently dephosphorylated yielding tuberculosinol (halima-5,13-dien-15-ol).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0035439
UniProtKB/Swiss-Prot:

References

  1. Nakano, C., Okamura, T., Sato, T., Dairi, T. and Hoshino, T.
    Mycobacterium tuberculosis H37 Rv3377c encodes the diterpene cyclase for producing the halimane skeleton.
    Chem. Commun. 1016-1018 (2005). [PMID: 15719101]

[EC 5.5.1.16 created 2008, modified 2012]