EC - syn-copalyl-diphosphate synthase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
syn-copalyl-diphosphate synthase
Other names:
syn-CPP synthase
syn-copalyl diphosphate synthase
9α-copalyl-diphosphate lyase (decyclizing)
Systematic name:
9α-copalyl-diphosphate lyase (ring-opening)




Requires a divalent metal ion, preferably Mg2+, for activity. This class II terpene synthase produces syn-copalyl diphosphate, a precursor of several rice phytoalexins, including oryzalexin S and momilactones A and B. Phytoalexins are diterpenoid secondary metabolites that are involved in the defense mechanism of the plant, and are produced in response to pathogen attack through the perception of elicitor signal molecules such as chitin oligosaccharide, or after exposure to UV irradiation. The enzyme is constitutively expressed in the roots of plants where one of its products, momilactone B, acts as an allelochemical (a molecule released into the environment to suppress the growth of neighbouring plants). In other tissues the enzyme is upregulated by conditions that stimulate the biosynthesis of phytoalexins.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0051498


  1. Otomo, K., Kenmoku, H., Oikawa, H., König, W.A., Toshima, H., Mitsuhashi, W., Yamane, H., Sassa, T. and Toyomasu, T.
    Biological functions of ent- and syn-copalyl diphosphate synthases in rice: key enzymes for the branch point of gibberellin and phytoalexin biosynthesis.
    Plant J. 39 : 886-893 (2004). [PMID: 15341631]
  2. Xu, M., Hillwig, M.L., Prisic, S., Coates, R.M. and Peters, R.J.
    Functional identification of rice syn-copalyl diphosphate synthase and its role in initiating biosynthesis of diterpenoid phytoalexin/allelopathic natural products.
    Plant J. 39 : 309-318 (2004). [PMID: 15255861]

[EC created 2008]