EC 220.127.116.11 - Methylornithine synthase
IntEnz Enzyme Nomenclature
The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes. Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The reaction is part of the biosynthesis pathway of pyrrolysine, a naturally occurring amino acid found in some archaeal methyltransferases.
Links to other databases
The complete biosynthesis of the genetically encoded amino acid pyrrolysine from lysine.Nature 471 : 647-650 (2011). [PMID: 21455182]
Crystal structure of methylornithine synthase (PylB): insights into the pyrrolysine biosynthesis.Angew. Chem. Int. Ed. Engl. 51 : 1339-1342 (2012). [PMID: 22095926]
[EC 18.104.22.168 created 2012]