EC 5.4.99.56 - Tirucalladienol synthase

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IntEnz Enzyme Nomenclature
EC 5.4.99.56

Names

Accepted name:
tirucalladienol synthase
Other name:
PEN3
Systematic name:
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, tirucalla-7,24-dien-3β-ol-forming)

Reaction

Comments:

The product from Arabidopsis thaliana is 85% tirucalla-7,24-dien-3β-ol with trace amounts of other triterpenoids.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Morlacchi, P., Wilson, W. K., Xiong, Q., Bhaduri, A., Sttivend, D., Kolesnikova, M. D., Matsuda, S. P.
    Product profile of PEN3: the last unexamined oxidosqualene cyclase in Arabidopsis thaliana.
    Org. Lett. 11 : 2627-2630 (2009). [PMID: 19445469]

[EC 5.4.99.56 created 2011]