EC 5.4.99.45 - TRNA pseudouridine38/39 synthase

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IntEnz Enzyme Nomenclature
EC 5.4.99.45

Names

Accepted name:
tRNA pseudouridine38/39 synthase
Other names:
Deg1
Pus3p
pseudouridine synthase 3
Systematic name:
tRNA-uridine38/39 uracil mutase

Reaction

Comments:

The enzyme from Saccharomyces cerevisiae is active only towards uridine38 and uridine39, and shows no activity with uridine40 (cf. EC 5.4.99.12, tRNA pseudouridine38-40 synthase) [1]. In vitro the enzyme from mouse is active on uridine39 and very slightly on uridine38 (human tRNALeu) [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0106029
UniProtKB/Swiss-Prot:

References

  1. Lecointe, F., Simos, G., Sauer, A., Hurt, E. C., Motorin, Y., Grosjean, H.
    Characterization of yeast protein Deg1 as pseudouridine synthase (Pus3) catalyzing the formation of Ψ38 and Ψ39 in tRNA anticodon loop.
    J. Biol. Chem. 273 : 1316-1323 (1998). [PMID: 9430663]
  2. Chen, J., Patton, J. R.
    Pseudouridine synthase 3 from mouse modifies the anticodon loop of tRNA.
    Biochemistry 39 : 12723-12730 (2000). [PMID: 11027153]

[EC 5.4.99.45 created 2011]