IntEnz - EC 5.4.99.3

EC 5 - Isomerases

EC 5.4 - Intramolecular transferases

EC 5.4.99 - Transferring other groups

EC 5.4.99.3 - 2-acetolactate mutase

IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 5.4.99.3

Names

Accepted name:

2-acetolactate mutase

Other names:

acetohydroxy acid isomerase
acetolactate mutase

Systematic name:

2-acetolactate methylmutase

Reactions

16361 [IUBMB]

2-acetolactate

2-acetolactate

Name origin: UniProt - CHECKED (C)

CHEBI:57774

Formula: C5H7O4
Charge: -1

ChEBI compound status: CHECKED (C)

=

3-hydroxy-3-methyl-2-oxobutanoate

3-hydroxy-3-methyl-2-oxobutanoate

Name origin: UniProt - CHECKED (C)

CHEBI:11812

Formula: C5H7O4
Charge: -1

ChEBI compound status: CHECKED (C)
25404

(S)-2-ethyl-2-hydroxy-3-oxobutanoate

(S)-2-ethyl-2-hydroxy-3-oxobutanoate

Name origin: UniProt - CHECKED (C)

CHEBI:49256

Formula: C6H9O4
Charge: -1

ChEBI compound status: CHECKED (C)

=

(R)-3-hydroxy-3-methyl-2-oxopentanoate

(R)-3-hydroxy-3-methyl-2-oxopentanoate

Name origin: UniProt - CHECKED (C)

CHEBI:49257

Formula: C6H9O4
Charge: -1

ChEBI compound status: CHECKED (C)

Cofactor

L-ascorbate

Comments:

Requires ascorbic acid; also converts 2-aceto-2-hydroxybutanoate to 3-hydroxy-3-methyl-2-oxopentanoate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway

Structural data: CSA , EC2PDB

Gene Ontology: GO:0047534

CAS Registry Number: 37318-52-8

References

Allaudeen, H.S. and Ramakrishnan, T.

Biosynthesis of isoleucine and valine in Mycobacterium tuberculosis H37 Rv.

Arch. Biochem. Biophys. 125: 199-209 (1968). [PMID: 4384955]

[EC 5.4.99.3 created 1972]