EC 5.4.3.6 - Tyrosine 2,3-aminomutase

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IntEnz Enzyme Nomenclature
EC 5.4.3.6

Names

Accepted name:
tyrosine 2,3-aminomutase
Other name:
tyrosine α,β-mutase
Systematic name:
L-tyrosine 2,3-aminomutase

Reaction

Cofactor

Comments:

The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO) [2]. This unique cofactor is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050368
CAS Registry Number: 9073-38-5
UniProtKB/Swiss-Prot:

References

  1. Kurylo-Borowska, Z. and Abramsky, T.
    Biosynthesis of β-tyrosine.
    Biochim. Biophys. Acta 264 : 1-10 (1972). [PMID: 5021987]
  2. Christianson, C.V., Montavon, T.J., Van Lanen, S.G., Shen, B. and Bruner, S.D.
    The structure of L-tyrosine 2,3-aminomutase from the C-1027 enediyne antitumor antibiotic biosynthetic pathway.
    Biochemistry 46 : 7205-7214 (2007). [PMID: 17516659]
  3. Christianson, C. V., Montavon, T. J., Festin, G. M., Cooke, H. A., Shen, B., Bruner, S. D.
    The mechanism of MIO-based aminomutases in β-amino acid biosynthesis.
    J. Am. Chem. Soc. 129 : 15744-15745 (2007). [PMID: 18052279]

[EC 5.4.3.6 created 1976]